Results 91 to 100 of about 47,347 (229)

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

Journal of Experimental & Clinical Cancer Research, 2023
Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage.
Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli   +11 more
doaj   +1 more source

Lysophosphatidic Acid Signaling in Diabetic Nephropathy [PDF]

International Journal of Molecular Sciences, 2019
Lysophosphatidic acid (LPA) is a bioactive phospholipid present in most tissues and body fluids. LPA acts through specific LPA receptors (LPAR1 to LPAR6) coupled with G protein. LPA binds to receptors and activates multiple cellular signaling pathways, subsequently exerting various biological functions, such as cell proliferation, migration, and ...
Jong Lee, Donghee Kim, Yoon Oh, Hee-Sook Jun   +3 more
openaire   +2 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Aggregation of Red Blood Cells: From Rouleaux to Clot Formation [PDF]

, 2013
Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the binding mechanism.
Steffen, P., Svetina, S., Wagner, C.
core   +2 more sources

Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice

Neurobiology of Pain, 2019
We developed a mouse model for central post-stroke pain (CPSP), a centrally-originated neuropathic pain (NeuP). In this mode, mice were first injected with Rose Bengal, followed by photo-irradiation of left middle cerebral artery (MCA) to generate ...
Hiroshi Ueda, Hiroyuki Neyama, Keita Sasaki, Chiho Miyama, Ryusei Iwamoto   +4 more
doaj   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study. [PDF]

PLoS ONE, 2017
Lysophosphatidic acid receptor 6 (LPAR6) is a G-protein coupled receptor (GPCR) involved in hair development and cytoskeleton formation in mammals. Its proliferation is implicated in several forms of cancer including liver cancer, squamous cell carcinoma
Saima Younis, Sajid Rashid
doaj   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]

, 2017
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio, Giustizieri, Michela, Leuti, Alessandro, Lombardi, Marta, Maccarrone, Mauro, Marinelli, Sara, Marinelli, Silvia, Marrone, Maria Cristina, Mattioli, Marzia, Morabito, Annunziato, Murana, Emanuele, Oddi, Sergio, Piomelli, Daniele, Ragozzino, Davide Antonio, Riganti, Loredana, Totaro, Antonio, Verderio, Claudia   +16 more
core   +3 more sources