Activation of lysophosphatidic acid receptor type 1 (LPA1) contributes to pathophysiology of spinal cord injury [PDF]
, 2015 Altres ajuts: NIH/NS084398Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions that signals through six known G-protein-coupled receptors (LPA1-LPA6).
Astudillo, Alma M. +9 more
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Autotaxin in Pathophysiology and Pulmonary Fibrosis
Frontiers in Medicine, 2018 Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in idiopathic pulmonary fibrosis (IPF) patients.
Ioanna Ninou +2 more
doaj +1 more source
Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control
The Journal of Physiology, EarlyView.
Richard J. A. Wilson +1 more
wiley +1 more source
Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid [PDF]
, 2003 To examine the contribution of different G-protein pathways to lysophosphatidic acid (LPA)-induced protein kinase D (PKD) activation, we tested the effect of LPA on PKD activity in murine embryonic cell lines deficient in Galpha q/11 (Galpha q/11 KO ...
Gu, Jennifer +3 more
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Lysophosphatidic acid receptors in cancer pathobiology.
Histology and histopathology, 2014 Lysophosphatidic acid (LPA) receptors (LPA₁ to LPA₆) are G protein-coupled transmembrane and mediate a variety of biological responses through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. Previously, high secretion levels of LPA were found in blood and ascites from patients with aggressive ovarian cancer.
Tsujiuchi, Toshifumi +4 more
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Structural insights into the committed step of bacterial phospholipid biosynthesis
Nature Communications, 2017 The first step in bacterial phospholipid biosynthesis is the acylation of glycerol 3-phosphate to form lysophosphatidic acid. Here, the authors present the high resolution crystal structure of the glycerol 3-phosphate acyltransferase PlsY, a membrane ...
Zhenjian Li +6 more
doaj +1 more source
Cytosolic Lysophosphatidic Acid Acyltransferase : Implications in Lipid Biosynthesis in Yeast, Plants and Human [PDF]
, 2008 Cytosolic LPA acyltransferase in yeast An isooctane tolerant strain of S. cerevisiae KK-12 was reported to have increased saturated fatty acid content (Miura et. al., 2000).
Ghosh, Ananda Kumar
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Biological & Pharmaceutical Bulletin, 2016 Lysophosphatidic acid (1-acyl-2-lyso-sn-glycero-3-phosphatidic acid; LPA) is a simple and minor phospholipid in plants. Plant LPAs are merely metabolic intermediates in de novo lipid synthesis in plant cell membranes or for glycerophospholipid storage.
Byung-Hwan, Lee +5 more
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The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders
Future PharmacologyIndividuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes.
Simona Dedoni +5 more
doaj +1 more source
LPAR2 Regulates LPA-Induced Osteoclast Sealing Zone Dynamics [PDF]
, 2010 Bone metastasis is an excruciating consequence of multiple primary cancers, and is commonly treated with bisphosphonate drugs. Osteoclasts, bone-resorbing cells vital to proper bone remodeling and fracture healing, are responsible for the formation of ...
Meyer, Stephanie
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