Results 111 to 120 of about 47,347 (229)

Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid [PDF]

, 2012
The objectives of this study were to investigate how diabetes mellitus (DM) influences responsiveness of retinal neovessels to lysophosphatidic acid (LPA) and to elucidate the underlying mechanism.
Aranda, Jorge, Im, Eunok, Kazlauskas, Andrius, Motiejunaite, Ruta   +3 more
core   +1 more source

Inhibitors of the Autotaxin-Lysophosphatidic Acid Axis and Their Potential in the Treatment of Interstitial Lung Disease: Current Perspectives

Clinical Pharmacology: Advances and Applications, 2020
Sabrina Zulfikar, Sarah Mulholland, Huzaifa Adamali, Shaney L Barratt Bristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, UKCorrespondence: Shaney L BarrattConsultant Respiratory Physician and Honorary Associate Researcher, North
Zulfikar S, Mulholland S, Adamali H, Barratt SL   +3 more
doaj  

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid [PDF]

, 2003
To examine the contribution of different G-protein pathways to lysophosphatidic acid (LPA)-induced protein kinase D (PKD) activation, we tested the effect of LPA on PKD activity in murine embryonic cell lines deficient in Galpha q/11 (Galpha q/11 KO ...
Gu, Jennifer, Rozengurt, Enrique, Slice, Lee W., Yuan, Jingzhen   +3 more
core  

Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [PDF]

, 2007
G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli.
New, David C., Wong, Yung Hou
core   +1 more source

Identification of Blood Pressure‐Associated Metabolites by Integrating Metabolomic and Genetic Analysis

MedComm, Volume 7, Issue 4, April 2026.
This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Yuanjiao Liu, Chunxiao Cheng, Xiong‐Fei Pan, Wei Shao, Dan Zhou, Yimin Zhu   +5 more
wiley   +1 more source

Spatial Elucidation of Spinal Cord Lipid- and Metabolite-Regulations in Amyotrophic Lateral Sclerosis [PDF]

, 2014
Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressing disease of the central nervous system that is characterized by motor neuron degeneration in the brain stem and the spinal cord.
Ewing, Andrew G, Hanrieder, Jörg
core   +2 more sources

From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer, Phoebe J. Leeming, Diana Stojanovski   +2 more
wiley   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

In Vitro Modeling of Age‐Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier, Mailys Portier, Chloe Heranney, Nancy Kouadio, Charles‐Antoine Arthaud, Marie‐Ange Eyraud, Marco Heestermans, Justine Bertrand‐Michel, Hind Hamzeh‐Cognasse, Fabrice Cognasse, Anne‐Claire Duchez   +10 more
wiley   +1 more source