Lysophosphatidic acid receptors in cancer pathobiology.
Histology and histopathology, 2014 Lysophosphatidic acid (LPA) receptors (LPA₁ to LPA₆) are G protein-coupled transmembrane and mediate a variety of biological responses through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. Previously, high secretion levels of LPA were found in blood and ascites from patients with aggressive ovarian cancer.
Tsujiuchi, Toshifumi +4 more
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Structural insights into the committed step of bacterial phospholipid biosynthesis
Nature Communications, 2017 The first step in bacterial phospholipid biosynthesis is the acylation of glycerol 3-phosphate to form lysophosphatidic acid. Here, the authors present the high resolution crystal structure of the glycerol 3-phosphate acyltransferase PlsY, a membrane ...
Zhenjian Li +6 more
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Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control
The Journal of Physiology, EarlyView.
Richard J. A. Wilson +1 more
wiley +1 more source
Biological & Pharmaceutical Bulletin, 2016 Lysophosphatidic acid (1-acyl-2-lyso-sn-glycero-3-phosphatidic acid; LPA) is a simple and minor phospholipid in plants. Plant LPAs are merely metabolic intermediates in de novo lipid synthesis in plant cell membranes or for glycerophospholipid storage.
Byung-Hwan, Lee +5 more
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The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders
Future PharmacologyIndividuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes.
Simona Dedoni +5 more
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Effect of Energy Metabolism on NF-kB activity in Ovarian Cancer [PDF]
, 2018 NF-kB is a transcription factor involved in cancer cell growth and survival. The activation of NF-kB can be assessed by monitoring phosphorylation of RelA p65 at Ser-536, which is a surrogate of the NF-kB transcription factor activation. The objective of
Bagri, Simren K
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Triacylglycerol synthesis in rat adipose tissue : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 1983 Adipose tissue consists of two types of cell; the adipocyte and the non-adipocyte {Rodbell, 1964). The adipocyte is unique amongst mammalian cell types in that one class of component {TG) comprises up to 80% of its weight.
Wilson, Russell Douglas
core
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]
, 2008 Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh +6 more
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Decreased plasma gelsolin in the COVID-19-related acute respiratory distress syndrome
Türk Biyokimya DergisiThe aim of this study was to evaluate the potential roles of plasma gelsolin (pGSN), transforming growth factor-beta1 (TGF-β1), and lysophosphatidic acid (LPA) as profibrotic and immune modulatory markers in patients with acute respiratory distress ...
Gunturk Inayet +5 more
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[Lysophosphatidic acid: a "bioactive" phospholipid].
Medecine sciences : M/S, 2004 Lysophosphatidic acid (LPA) is a "bioactive" phospholipid able to generate growth factor-like activities in a wide variety of normal and malignant cell types. LPA is proposed to play an important role in normal physiological situations such as wound healing, vascular tone, vascular integrity, or reproduction.
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