Results 51 to 60 of about 47,686 (230)

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2016
Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA-LPA1 signaling contributes to pulmonary fibrosis, here we investigated whether this pathway is also involved in lung development.
Manuela, Funke, Lars, Knudsen, David, Lagares, Simone, Ebener, Clemens K, Probst, Benjamin A, Fontaine, Alicia, Franklin, Manuela, Kellner, Mark, Kühnel, Stephanie, Matthieu, Roman, Grothausmann, Jerold, Chun, Jesse D, Roberts, Matthias, Ochs, Andrew M, Tager   +14 more
openaire   +2 more sources

Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis

JACC: Basic to Translational Science, 2017
Summary: The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory.
Michael Torzewski, MD, Amir Ravandi, MD, PhD, Calvin Yeang, MD, PhD, Andrea Edel, PhD, Rahul Bhindi, MD, Stefan Kath, MD, Laura Twardowski, MD, Jens Schmid, PhD, Xiaohong Yang, BS, Ulrich F.W. Franke, MD, Joseph L. Witztum, MD, Sotirios Tsimikas, MD   +11 more
doaj   +1 more source

Role of autotaxin in systemic lupus erythematosus

Frontiers in Medicine, 2023
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease characterized by the production of various autoantibodies and deposition of immune complexes.
Yumi Tsuchida, Hirofumi Shoda, Tetsuji Sawada, Keishi Fujio   +3 more
doaj   +1 more source

A single amino acid determines preference between phospholipids and reveals length restriction for activation ofthe S1P₄ receptor [PDF]

, 2004
Background<br/><br/> Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively.
Fells, J.I., Holdsworth, G., Hutchinson, G., Milligan, G., Osborne, D.A., Parrill, A.L., Thi Pham, T.   +6 more
core   +3 more sources

Human Lysophosphatidic Acid Acyltransferase [PDF]

Journal of Biological Chemistry, 1997
DNA and polypeptide sequences of a human lysophosphatidic acid acyltransferase (LPAAT) are disclosed. Methods and materials for production of LPAAT-1 and fragments and analogs thereof, production of antibodies, assays for identifying modulators of LPAAT and pharmaceutical compositions comprising LPAAT, polypeptides or modulators of LPAAT are provided ...
Christine Eberhardt, Patrick W. Gray, Larry W. Tjoelker   +2 more
openaire   +1 more source

Akurasi Kadar Lysophosphatidic Acid Plasma dan Ca125 Serum Penderita Tumor Ovarium Jenis Epitel untuk Prediktor Keganasan Ovarium

Indonesian Journal of Cancer, 2014
This study was conducted to determine and compare the sensitivity, specificity, positive predictive value and negative predictive value between CA125, Lysophosphatidic Acid Plasma (LPA) and combination of LPA - CA125 in patients with ovarian mass ...
TRI APRILIAWAN, BRAHMANA ASKANDAR
doaj   +1 more source

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling. [PDF]

PLoS ONE, 2013
Lysophosphatidic acid acyltransferase (LPAAT-β) is a phosphatidic acid (PA) generating enzyme that plays an essential role in triglyceride synthesis. However, LPAAT-β is now being studied as an important regulator of cell growth and differentiation and ...
Michelle A Blaskovich, Vimala Yendluri, Harshani R Lawrence, Nicholas J Lawrence, Saïd M Sebti, Gregory M Springett   +5 more
doaj   +1 more source

Lysophosphatidic acid signalling in development

Development, 2015
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology.
Xiaoyan, Sheng, Yun C, Yung, Allison, Chen, Jerold, Chun   +3 more
openaire   +3 more sources

Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. [PDF]

, 2017
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy ...
Erle, David J, Heyder, Tina, Kamleh, Muhammad Anas, Kolmert, Johan, Levänen, Bettina, Naz, Shama, Reinke, Stacey N, Sköld, C Magnus, Snowden, Stuart, Wheelock, Craig E, Wheelock, Åsa M, Yang, Mingxing   +11 more
core   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source