Results 51 to 60 of about 47,347 (229)

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2016
Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA-LPA1 signaling contributes to pulmonary fibrosis, here we investigated whether this pathway is also involved in lung development.
Manuela, Funke, Lars, Knudsen, David, Lagares, Simone, Ebener, Clemens K, Probst, Benjamin A, Fontaine, Alicia, Franklin, Manuela, Kellner, Mark, Kühnel, Stephanie, Matthieu, Roman, Grothausmann, Jerold, Chun, Jesse D, Roberts, Matthias, Ochs, Andrew M, Tager   +14 more
openaire   +2 more sources

Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. [PDF]

, 2017
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy ...
Erle, David J, Heyder, Tina, Kamleh, Muhammad Anas, Kolmert, Johan, Levänen, Bettina, Naz, Shama, Reinke, Stacey N, Sköld, C Magnus, Snowden, Stuart, Wheelock, Craig E, Wheelock, Åsa M, Yang, Mingxing   +11 more
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Akurasi Kadar Lysophosphatidic Acid Plasma dan Ca125 Serum Penderita Tumor Ovarium Jenis Epitel untuk Prediktor Keganasan Ovarium

Indonesian Journal of Cancer, 2014
This study was conducted to determine and compare the sensitivity, specificity, positive predictive value and negative predictive value between CA125, Lysophosphatidic Acid Plasma (LPA) and combination of LPA - CA125 in patients with ovarian mass ...
TRI APRILIAWAN, BRAHMANA ASKANDAR
doaj   +1 more source

Human Lysophosphatidic Acid Acyltransferase [PDF]

Journal of Biological Chemistry, 1997
DNA and polypeptide sequences of a human lysophosphatidic acid acyltransferase (LPAAT) are disclosed. Methods and materials for production of LPAAT-1 and fragments and analogs thereof, production of antibodies, assays for identifying modulators of LPAAT and pharmaceutical compositions comprising LPAAT, polypeptides or modulators of LPAAT are provided ...
Christine Eberhardt, Patrick W. Gray, Larry W. Tjoelker   +2 more
openaire   +1 more source

Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts [PDF]

, 2006
Previous observations of association of mRNAs and ribosomes with subcellular structures highlight the importance of localised translation. However, little is known regarding associations between eukaryotic translation initiation factors and cellular ...
Barbarese, Bassell, Bergamini, Biegel, Bonneau, Bushell, Bushell, Caron, Carson, Cervera, Chicurel, Clore, Coldwell, Cowan, Cuesta, Culjkovic, Dang, Delom, Farina, Farmer, Hamill, Hasek, Hill, Hou, Hovland, Hudder, Jansen, Jansen, Jockusch, Kedersha, Kedersha, Kedersha, Kedersha, Kim, Kimball, Kislauskis, Kloc, Latham, Lemieux, Lenk, Lerner, Lerner, Levadoux, Lin, Lindemann, Liu, Mark Willett, Mickleburgh, Micklem, Moore, Moore, Munshi, Murray, Negrutskii, Negrutskii, Negrutskii, Nicchitta, Ornelles, Palacek, Patrick, Pincheira, Prahlad, Pramanik, Prevot, Ramaekers, Shestakova, Simon A. Flint, Simon J. Morley, Smart, Stapulionis, Stapulionis, Svitkin, Svitkin, Taneja, Thoma, Traub, Trombetta, Umikawa, Valouev, van Venrooij, Virginia M. Pain, Wang, Woods   +82 more
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Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis

JACC: Basic to Translational Science, 2017
Summary: The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory.
Michael Torzewski, MD, Amir Ravandi, MD, PhD, Calvin Yeang, MD, PhD, Andrea Edel, PhD, Rahul Bhindi, MD, Stefan Kath, MD, Laura Twardowski, MD, Jens Schmid, PhD, Xiaohong Yang, BS, Ulrich F.W. Franke, MD, Joseph L. Witztum, MD, Sotirios Tsimikas, MD   +11 more
doaj   +1 more source

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling. [PDF]

PLoS ONE, 2013
Lysophosphatidic acid acyltransferase (LPAAT-β) is a phosphatidic acid (PA) generating enzyme that plays an essential role in triglyceride synthesis. However, LPAAT-β is now being studied as an important regulator of cell growth and differentiation and ...
Michelle A Blaskovich, Vimala Yendluri, Harshani R Lawrence, Nicholas J Lawrence, Saïd M Sebti, Gregory M Springett   +5 more
doaj   +1 more source

Lysophosphatidic acid signalling in development

Development, 2015
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology.
Xiaoyan, Sheng, Yun C, Yung, Allison, Chen, Jerold, Chun   +3 more
openaire   +3 more sources

Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]

, 2015
Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee, Coleman, Rosalind A., Garcia Fabiani, Maria Belen, Gonzalez-Baró, Lacunza, Ezequiel, Montanaro, Mauro Aldo, Pellon Maison, Magali   +6 more
core   +2 more sources

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. [PDF]

, 2016
With the passing of Dr. Robert Bittman from pancreatic cancer on the 1st October 2014, the lipid research field lost one of the most influential and significant personalities.
Pyne, Nigel J., Tigyi, Gabor J.
core   +1 more source