Results 81 to 90 of about 47,686 (230)

Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]

, 2002
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L., Mancino, Valeria, Müller, Stefan, Offermanns, Stefan, Simon, Melvin I.   +4 more
core  

Sublytic Terminal Complement Components Induce Eryptosis in Autoimmune Haemolytic Anaemia Related to IgM Autoantibodies [PDF]

, 2019
BACKGROUND/AIMS: Eryptosis, the suicidal death of red blood cells (RBCs), is characterized by phosphatidylserine (PS) exposure at the cell surface. It can be catalysed by a variety of abnormal conditions and diseases.
Balola, Abdelwahab Hassan Ahmed, Bartolmäs, Thilo, Mayer, Beate, Salama, Abdulgabar   +3 more
core   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain

Molecular Pain, 2009
Background We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX).
Aoki Junken, Chun Jerold, Inoue Makoto, Nagai Jun, Uchida Hitoshi, Ma Lin, Ueda Hiroshi   +6 more
doaj   +1 more source

A minimal biochemical route towards de novo formation of synthetic phospholipid membranes. [PDF]

, 2019
All living cells consist of membrane compartments, which are mainly composed of phospholipids. Phospholipid synthesis is catalyzed by membrane-bound enzymes, which themselves require pre-existing membranes for function.
Bhattacharya, Ahanjit, Brea, Roberto J, Devaraj, Neal K, Niederholtmeyer, Henrike   +3 more
core   +2 more sources

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

Journal of Experimental & Clinical Cancer Research, 2023
Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage.
Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli   +11 more
doaj   +1 more source

Storage oil hydrolysis during early seedling growth [PDF]

, 2009
Storage oil breakdown plays an important role in the life cycle of many plants by providing the carbon skeletons that support seedling growth immediately following germination.
Andrews, Anne-Laure Quettier, Athenstaedt, Athenstaedt, Baker, Beisson, Chia, Ducharme, Eastmond, Eastmond, Eastmond, El-Kouhen, Fernandez, Frandsen, Fuchs, Fuchs, Ghosh, Ghosh, Graham, Grönke, Gupta, Hayashi, Hellyer, Hills, Hills, Hills, Huang, Ishiguro, Jennens, Jolivet, Kurat, Lass, Lin, Lin, Maeshima, Matsui, May, Mhaske, Mukherjee, Murphy, Murphy, Ncube, Noll, Ohlrogge, Ollis, Peter J. Eastmond, Poxleitner, Quettier, Robenek, Rydel, Schweiger, Siloto, Somerville, Stahl, Ubersax, Wanner, Zimmermann   +56 more
core   +1 more source

Optical Control of Lysophosphatidic Acid Signaling

Journal of the American Chemical Society, 2020
Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and activates the family of lysophosphatidic acid receptors (LPA1-6). These G protein-coupled receptors (GPCRs) are broadly expressed and are particularly important in development as well as in the nervous, cardiovascular, reproductive, gastrointestinal, and ...
Johannes Morstein, Mélanie A. Dacheux, Derek D. Norman, Andrej Shemet, Prashant C. Donthamsetti, Mevlut Citir, James A. Frank, Carsten Schultz, Ehud Y. Isacoff, Abby L. Parrill, Gabor J. Tigyi, Dirk Trauner   +11 more
openaire   +5 more sources

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective

Plant Biotechnology Journal, EarlyView.
ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi‐Yan Du   +6 more
wiley   +1 more source

Lysophosphatidic Acid Signaling in Diabetic Nephropathy [PDF]

International Journal of Molecular Sciences, 2019
Lysophosphatidic acid (LPA) is a bioactive phospholipid present in most tissues and body fluids. LPA acts through specific LPA receptors (LPAR1 to LPAR6) coupled with G protein. LPA binds to receptors and activates multiple cellular signaling pathways, subsequently exerting various biological functions, such as cell proliferation, migration, and ...
Jong Lee, Donghee Kim, Yoon Oh, Hee-Sook Jun   +3 more
openaire   +2 more sources