Frontiers in Molecular Neuroscience, 2020 Lysophosphatidic acid is a small extracellular signaling molecule, which is elevated in pathological conditions such as ischemic stroke and traumatic brain injury (TBI). LPA regulates the survival of neurons in various diseases.
Jie Zhang +6 more
doaj +1 more source
Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis
Molecules, 2022 The ATX-LPA-LPAR1 signaling pathway plays a universal role in stimulating diverse cellular responses, including cell proliferation, migration, survival, and invasion in almost every cell type.
Souvik Banerjee +3 more
doaj +1 more source
Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts [PDF]
, 2016 Background and Purpose Human lung fibroblasts (HLF) express high levels of the LPA1 receptor, a GPCR that responds to the endogenous lipid mediator, lysophosphatidic acid (LPA).
Dowling, Mark R, +2 more
core +2 more sources
Autotaxin in Pathophysiology and Pulmonary Fibrosis
Frontiers in Medicine, 2018 Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in idiopathic pulmonary fibrosis (IPF) patients.
Ioanna Ninou +2 more
doaj +1 more source
Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions [PDF]
, 2015 Several clinical trials are exploring therapeutic effect of human CD34(+) cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery.
Aday, S +11 more
core +1 more source
Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis [PDF]
Biochemical Society Transactions, 2012 LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-like lipid mediator that regulates many cellular functions, many of which are unique to malignantly transformed cells. The simple chemical structure of LPA and its profound effects in cancer cells has attracted the attention of the cancer therapeutics field and ...
Mari, Gotoh +14 more
openaire +3 more sources
Journal of Ginseng Research, 2019 Background: Gintonin is a ginseng-derived exogenous ligand of the G protein-coupled lysophosphatidic acid (LPA) receptor. We previously reported that gintonin stimulates gliotransmitter release in primary cortical astrocytes. Astrocytes play key roles in
Sun-Hye Choi +9 more
doaj +1 more source
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]
, 2017 PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson +82 more
core +3 more sources
Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade [PDF]
Arthritis Research & Therapy, 2014 Abstract Introduction Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein-coupled receptors (LPA1-6). Recently, we reported that abrogation of LPA receptor 1 (LPA1) ameliorated murine collagen-induced arthritis, probably via inhibition of inflammatory cell migration, Th17 ...
Miyabe, Yoshishige +9 more
openaire +2 more sources
Lysophosphatidic Acid Induces Migration of Human Lung‐Resident Mesenchymal Stem Cells Through the β‐Catenin Pathway [PDF]
, 2012 Mesenchymal stem cells (MSCs) have been demonstrated to reside in human adult organs. However, mechanisms of migration of these endogenous MSCs within their tissue of origin are not well understood.
Anliker +33 more
core +1 more source