Results 1 to 10 of about 39,610 (238)

Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study [PDF]

Journal of Lipid Research
DHA is primarily found in fish and seafood as triacylglycerols and phospholipids (PLs). Oral administration of PL DHA forms, sn-1 lysophosphatidylcholine-DHA (sn-1 LPC-DHA) and di-DHA phosphatidylcholine (di-DHA-PC), has been suggested to increase brain ...
Brinley J. Klievik, Yan Fu, Aidan D. Tyrrell, Chuck T. Chen, Adam H. Metherel, Richard P. Bazinet   +5 more
doaj   +2 more sources

iPLA₂β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury

Cells, 2021
Both calcium-independent phospholipase A2 beta (iPLA2β) and endoplasmic reticulum (ER) stress regulate important pathophysiological processes including inflammation, calcium homeostasis and apoptosis.
Tingting Jin, Jun Lin, Yingchao Gong, Xukun Bi, Shasha Hu, Qingbo Lv, Jiaweng Chen, Xiaoting Li, Jiaqi Chen, Wenbin Zhang, Meihui Wang, Guosheng Fu   +11 more
doaj   +1 more source

Prediction model and application value of lysophosphatidylcholine in evaluation for donor liver quality

Di-san junyi daxue xuebao, 2021
Objective To explore the alteration profile of lysophosphatidylcholine (LPC) content in donor liver with the elapse of total ischemic time and investigate its application value in the evaluation of donor liver quality. Methods A total of 100 patients who
WANG Hong, OU Yanjiao, HU Peng, LIU Wei, LI Chuanhong, ZHANG Leida   +5 more
doaj   +1 more source

Imipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes

Biomolecules, 2023
Lysosomes are degradative organelles that facilitate the removal and recycling of potentially cytotoxic materials and mediate a variety of other cellular processes, such as nutrient sensing, intracellular signaling, and lipid metabolism.
Jacob M. Albright, Matthew J. Sydor, Jonathan Shannahan, Christina R. Ferreira, Andrij Holian   +4 more
doaj   +1 more source

Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes

Cells, 2023
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood.
Thomas Timm, Christiane Hild, Gerhard Liebisch, Markus Rickert, Guenter Lochnit, Juergen Steinmeyer   +5 more
doaj   +1 more source

Lysophosphatidylcholine Alleviates Acute Lung Injury by Regulating Neutrophil Motility and Neutrophil Extracellular Trap Formation

Frontiers in Cell and Developmental Biology, 2022
Sepsis is predominantly initiated by bacterial infection and can cause systemic inflammation, which frequently leads to rapid death of the patient. However, this acute systemic inflammatory response requires further investigation from the perspectives of
Soi Jeong, Soi Jeong, Bora Kim, Da Jeong Byun, Da Jeong Byun, Sunmin Jin, Bo Seung Seo, Mi Hwa Shin, Ah Young Leem, Jai Jun Choung, Moo Suk Park, Young-Min Hyun, Young-Min Hyun   +12 more
doaj   +1 more source

ATP Release Drives Inflammation with Lysophosphatidylcholine [PDF]

ImmunoHorizons, 2020
Abstract Lysophosphatidylcholine (LPC), a dominant lipid component of oxidized low-density lipoprotein, plays a major role in inflammation associated with atherosclerosis and neurodegenerative disorders. It activates inflammatory responses from macrophages, neuronal cells, and endothelial cells.
Sana, Ismaeel, Ayub, Qadri
openaire   +3 more sources

Dantrolene inhibits lysophosphatidylcholine-induced valve interstitial cell calcific nodule formation via blockade of the ryanodine receptor

Frontiers in Cardiovascular Medicine, 2023
Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is
Christopher B. Sylvester, Christopher B. Sylvester, Farshad Amirkhosravi, Farshad Amirkhosravi, Angelina S. Bortoletto, Angelina S. Bortoletto, William J. West, William J. West, Jennifer P. Connell, K. Jane Grande-Allen   +9 more
doaj   +1 more source

Synthesis of Lysophosphatidylcholine and Mixed Phosphatidylcholine [PDF]

The Journal of Organic Chemistry, 2022
Lysophosphatidylcholine (LPC) and phosphatidylcholine (PC) are important membrane constituents implicated in signaling and immune regulation. Synthesis of LPCs is challenging due to rapid acyl migration, e.g., induced by chromatography. We here report a highly regioselective synthesis of LPC and mixed PC via an intermediate allowing specific terminal ...
Athanasios Papangelis, Trond Ulven
openaire   +3 more sources

Effects of Lysophosphatidylcholine on Jejuna Morphology and Its Potential Mechanism

Frontiers in Veterinary Science, 2022
Lysophosphatidylcholine (LPC) plays a vital role in promoting jejuna morphology in broilers. However, the potential mechanism behind LPC improving the chicken jejuna morphology is unclear. Therefore, the present study was designed to reveal the important
Xiaofeng Li, Abdel-Moneim Eid Abdel-Moneim, Noura M. Mesalam, Bing Yang   +3 more
doaj   +1 more source