Results 11 to 20 of about 39,610 (238)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Involvement of the lysosome in the catabolism of intracellular lysophosphatidylcholine and evidence for distinct pools of lysophosphatidylcholine.

Journal of Lipid Research, 1993
The role of the lysosome in the metabolism of lysophosphatidylcholine was investigated in isolated rat hepatocytes. Chloroquine, primaquine, and ammonium chloride caused a 2.5-fold increase in radioactive lysophosphatidylcholine in [methyl-3H]choline ...
GM Hatch, A Oskin, DE Vance
doaj   +1 more source

Phospholipases and Reactive Oxygen Species Derived Lipid Biomarkers in Healthy and Diseased Humans and Animals – A Focus on Lysophosphatidylcholine

Frontiers in Physiology, 2021
Phospholipids (PL) are converted into lipid biomarkers by the action of phospholipases and reactive oxygen species (ROS), which are activated or released under certain physiological and pathophysiological conditions.
Kathrin M. Engel, Jürgen Schiller, Christina E. Galuska, Beate Fuchs   +3 more
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids

Journal of Lipid Research, 2001
Lysophosphatidylcholine is an abundant component of plasma and oxidized LDL that displays several biological activities, some of which may occur through the platelet-activating factor (PAF) receptor.
Gopal K. Marathe, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre   +6 more
doaj   +1 more source

The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism

Biomolecules, 2023
The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent ...
Sayaka Harada, Yoshitaka Taketomi, Toshiki Aiba, Mai Kawaguchi, Tetsuya Hirabayashi, Baasanjav Uranbileg, Makoto Kurano, Yutaka Yatomi, Makoto Murakami   +8 more
doaj   +1 more source

Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: effect of nutritionally induced atherosclerosis

Journal of Lipid Research, 1969
The concentration of lysophosphatidylcholine (monoacyl sn-glycerol 3-phosphorylcholine) in intima plus inner media of atherosclerotic aorta from squirrel monkeys was nearly eight times that in comparable control tissue. Plasma levels of the same compound
Oscar W. Portman, Manfred Alexander
doaj   +1 more source

Preserved and variable spatial‐chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade

Plant-Environment Interactions, 2021
Membrane lipids serve as substrates for the generation of numerous signaling lipids when plants are exposed to environmental stresses, and jasmonic acid, an oxidized product of 18‐carbon unsaturated fatty acids (e.g., linolenic acid), has been recognized
Dušan Veličković, Rosalie K. Chu, Corinna Henkel, Annika Nyhuis, Nannan Tao, Jennifer E. Kyle, Joshua N. Adkins, Christopher R. Anderton, Vanessa Paurus, Kent Bloodsworth, Lisa M. Bramer, Dale S. Cornett, Wayne R. Curtis, Kristin E. Burnum‐Johnson   +13 more
doaj   +1 more source

Cancer therapy-induced PAFR ligand expression: any role for caspase activity? [PDF]

, 2017
No abstract ...
G Ichim, Gabriel Ichim, K Lauber, Q Huang, RP Sahu, RP Sahu, Stephen W. G. Tait, X Zhao   +7 more
core   +1 more source

A sensitive method for the quantitation of lysophosphatidylcholine in canine heart.

Journal of Lipid Research, 1985
We have developed a procedure for the determination of small amounts of lysophosphatidylcholine in cardiac tissue. Lysophosphatidylcholine from canine heart was separated from the major phospholipids by column chromatography, and then acetylated with ...
M Wientzek, G Arthur, R Y Man, P C Choy
doaj   +1 more source