Results 31 to 40 of about 7,434 (235)

Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology [PDF]

, 2019
Introduction: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD.
Arnold, Matthias, Baillie, Rebecca, Barupal, Dinesh Kumar, Consortium, Alzheimer Disease Metabolomics, Fan, Sili, Fiehn, Oliver, Initiative, Alzheimer's Disease Neuroimaging, Kaddurah‐Daouk, Rima, Meikle, Peter J, Nho, Kwangsik, Saykin, Andrew J   +10 more
core   +2 more sources

Continuous fluorescence assay for lecithin:cholesterol acyltransferase using a water-soluble phosphatidylcholine.

Journal of Lipid Research, 1992
A water-soluble fluorescent phosphatidylcholine, 1,2-bis[4-(1-pyreno-butanoyl]-sn-glycero-3-phosphocholine (DPybPC) has been used to develop a sensitive, continuous assay for pure lecithin:cholesterol acyltransferase (LCAT) in solution.
FS Bonelli, A Jonas
doaj   +1 more source

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma [PDF]

, 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis.
Ana Gomes, Ana M. Gil, António S. Barros, Asiago V. M., Bathe O. F., Bell J. D., Brian J. Goodfellow, Brière J.-J., Carrola J., Cláudia M. Rocha, Daykin C. A., Dong J., Duarte I. F., Duarte I. F., Erol A., Fan T. W. M., Fiorenza A. M., Fiorenza A. M., Freedman D. S., Gao H., Gao H. C., Gu H. W., Haffner H. T., Heber D., Iola F. Duarte, Isabel M. Carreira, Joana Carrola, João Bernardo, Jordan K. W., Keun H. C., Kochhar S., Lai H.-S., Laiakis E. C., Lin L., Lina Carvalho, Liu M., Lokhov P. G., Ludwig C., Ma Y., MacIntyre D. A., Maeda J., Muntoni S., Naini A. B., Norton J. A., Okamoto N., Pirozynski M., Psychogios N., Qiu Y. P., Ritchie S. A., Rocha C. M., Sitter B., Spratlin J. L., Sreekumar A., Stringer K. A., Thysell E., Tiziani S., Travis W. D., Trygg J., Urayama S., Vitor Sousa, Xu Q. S., Xue R., Yin P., Zhang J. A., Zhang Z. Y., Zhou J., Zira A. N.   +66 more
core   +2 more sources

Lysophosphatidylcholine-cholesterol complex.

Journal of Biological Chemistry, 1982
Lysophosphatidylcholine (lysoPC) and cholesterol at 1:1 molar ratio form multilamellar and, on sonication, unilamellar liposomes in water. Calorimetric scannings of varied mixtures in water give evidence for the existence of a 1:1 complex of the lipids.
L S, Ramsammy, H, Brockerhoff
openaire   +2 more sources

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles [PDF]

, 2013
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest
Adamski, J. (Jerzy), Aulchenko, Y.S. (Yurii), Axenovich, T.I. (Tatiana), Biloglav, Z. (Zrinka), Broer, L. (Linda), Campbell, H. (Harry), Campbell, S. (Susan), Demirkan, A. (Ayşe), Dharuri, H. (Harish), Domingues, I. (Inês), Duijn, C.M. (Cornelia) van, Floyd, J. (Jamie), Franke, L. (Lude), Franklin, C.S. (Christopher), Gieger, C. (Christian), Gnewuch, C. (Carsten), Gyllensten, U. (Ulf), Hastie, N. (Nick), Hayward, C. (Caroline), Henneman, P. (Peter), Hettne, K.M. (Kristina), Hicks, A.A. (Andrew), Hoen, P.A.C. (Peter) 't, Hofman, A. (Albert), Huffman, J.E. (Jennifer), Igl, W. (Wilmar), Isaacs, A.J. (Aaron), Jansen, R.C. (Ritsert), Janssens, A.C.J.W. (Cécile), Johansson, A. (Åsa), Jonasson, I. (Inger), Karssen, L.C. (Lennart), Kirichenko, A.V. (Anatoly), Klinken, J.B. (Jan) van, Kolcic, I. (Ivana), Liebisch, G. (Gerhard), Meitinger, T. (Thomas), Mook-Kanamori, D.O. (Dennis), Oostra, B.A. (Ben), Pattaro, C. (Cristian), Pfeufer, A. (Arne), Pichler, I. (Irene), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Rivadeneira Ramirez, F. (Fernando), Roos, M. (Marco), Rudan, I. (Igor), Schmitz, G. (Gerd), Struchalin, M.V. (Maksim), Suhre, K. (Karsten), Ugocsai, P. (Peter), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Wang-Sattler, R. (Rui), Wild, S.H. (Sarah), Willems van Dijk, J.A.P. (Ko), Wilson, J.F. (James F), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Zaboli, G. (Ghazal), Zorkoltseva, I.V. (Irina)   +60 more
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Lysophosphatidylcholine Drives Neuroblast Cell Fate

Molecular Neurobiology, 2015
Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions.
Paoletti, Luciana Elisa, Domizi, Pablo Daniel, Marcucci, Hebe Josefina, Montaner, Aneley Natalia, Krapf, Dario, Salvador, Gabriela Alejandra, Banchio, Claudia Elena   +6 more
openaire   +3 more sources

Maternal and fetal metabolomic signatures in regard to birth outcome and gestational disease [PDF]

, 2018
Specific birth outcomes and gestational diabetes were shown to be associated with maternal and fetal metabolic alterations. Results of the current studies showed a higher number of associations between birth outcomes/gestational disease and fetal ...
Lu, YongPing
core   +1 more source

Immunomodulatory Actions of Lysophosphatidylcholine [PDF]

Biomolecules and Therapeutics, 2008
Lysophosphatidylcholine (LPC) is an endogenous phospholipid. LPC has various stimulating or modulating activities on immune cells, including lymphocytes, monocytes/macrophages and neutrophils. Stud- ies generally revealed pro-inflammatory activities of LPC, but accumulating evidence indicates that LPC has also anti-inflammatory actions.
Chang-Won Hong, Dong-Keun Song
openaire   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources