Results 71 to 80 of about 7,434 (235)

Association between the third trimester maternal serum metabolome and child growth and development through the first year of life

Scientific Reports
Evidence suggests that maternal metabolome may be associated with child health outcomes. We analyzed the association between the maternal metabolome between 28–35 gestational weeks and child growth and development during the first year.
Samary da Silva Rosa Freire, Marina Padilha, Ana Lorena Lima Ferreira, Raquel Machado Schincaglia, Amanda Caroline Cunha Figueiredo, Nathalia Cristina Freitas-Costa, Xiaofei Yin, Lorraine Brennan, Gilberto Kac   +8 more
doaj   +1 more source

Accumulation of alkyl-lysophosphatidylcholines in Niemann-Pick disease type C1

Journal of Lipid Research
Lysosomal function is impaired in Niemann-Pick disease type C1 (NPC1), a rare and inherited neurodegenerative disorder, resulting in late endosomal/lysosomal accumulation of unesterified cholesterol.
Sonali Mishra, Pamela Kell, David Scherrer, Dennis J. Dietzen, Charles H. Vite, Elizabeth Berry-Kravis, Cristin Davidson, Stephanie M. Cologna, Forbes D. Porter, Daniel S. Ory, Xuntian Jiang   +10 more
doaj   +1 more source

Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro

Cell Reports, 2022
Summary: Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection
Joann Diray-Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, Matthew A. Pettengill, Mark Liu, Simon D. van Haren, Scott D. McCulloch, Greg Michelloti, Olubukola Idoko, Tobias R. Kollmann, Beate Kampmann, Hanno Steen, Al Ozonoff, Jessica Lasky-Su, Christine S. Benn, Ofer Levy   +17 more
doaj   +1 more source

Chemical mechanism of lysophosphatidylcholine: lysophosphatidylcholine acyltransferase from rabbit lung. pH-dependence of kinetic parameters [PDF]

Biochemical Journal, 1990
Lysophosphatidylcholine: lysophosphatidylcholine acyltransferase is an enzyme that catalyses two reactions: hydrolysis of lysophosphatidylcholine and transacylation between two molecules of lysophosphatidylcholine to give disaturated phosphatidylcholine.
J, Pérez-Gil, J, Martín, C, Acebal, R, Arche   +3 more
openaire   +2 more sources

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Co-Transplantation of Human Neurotrophic Factor Secreting Cells and Adipose-Derived Stem Cells in Rat Model of Multiple Sclerosis

Cell Journal, 2018
Objective The presence of neurotrophic factors is critical for regeneration of neural lesions. Here, we transplanted combination of neurotrophic factor secreting cells (NTF-SCs) and human adipose derived stem cells (hADSCs) into a lysolecithin model of ...
Shahnaz Razavi, Nazem Ghasemi, Mohammad Mardani, Hossein Salehi   +3 more
doaj   +1 more source

Lysophosphatidylcholine inhibits membrane‐associated SNARE complex disassembly [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractIn cells, N‐ethylmaleimide‐sensitive factor (NSF) attachment protein receptors called SNAREs are involved in membrane fusion. In neurons, for example, target membrane proteins SNAP‐25 and syntaxin called t‐SNAREs present at the pre‐synaptic membrane, and a synaptic vesicle‐associated membrane protein (VAMP) or v‐SNARE, is part of the conserved ...
Shin, Leah, Wang, Sunxi, Lee, Jin-Sook, Flack, Amanda, Mao, Guangzhao, Jena, Bhanu P   +5 more
openaire   +2 more sources

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. [PDF]

, 2016
PI3K plays a key role in cellular metabolism and cancer. Using a mass spectrometry-based metabolomics platform, we discovered that plasma concentrations of 26 metabolites, including amino acids, acylcarnitines, and phosphatidylcholines, were decreased in
Alan T. Henley, Alexis de Haven Brandon, Banerjee, Bart Vanhaesebroeck, Chegary, Florence I. Raynaud, Gary Box, Johann S. de Bono, Joo Chew Ang, Joo Ern Ang, Lori Friedman, Melanie Valenti, Mika Derynck, Paul Workman, Richard D. Baird, Rupinder Pandher, Stan B. Kaye, Suzanne A. Eccles, Svensson, Yasmin J. Asad   +19 more
core   +2 more sources

Interference of lysophosphatidylcholine in hormone radioimmunoassays

Clinical Chemistry, 1993
Abstract The interference of synthetic and naturally occurring detergents in immunoassays is well documented. In the present study, we evaluated the effect of lysophosphatidylcholine (LPC) and found that the lysophospholipid interfered with formation of the antigen-antibody complex in hormone immunoassays.
N, Lepage, K D, Roberts, J, Langlais
openaire   +2 more sources