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Lysophospholipids and the cardiovascular system
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis. These molecules may exert potentially detrimental effects.
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Biological effects of lysophospholipids
2006Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
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Lysophospholipids as Mediators of Immunity
2006Lysophospholipids (LPLs) are lipid-derived signaling molecules exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Originally identified as serum-associated growth factors, these mediators now are known to signal through a family of diverse G protein-coupled receptors (GPCRs). Virtually all cells that participate in the immune
Debby A, Lin, Joshua A, Boyce
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Lysophospholipids in Lung Inflammatory Diseases
2021The lysophospholipids (LPLs) belong to a group of bioactive lipids that play pivotal roles in several physiological and pathological processes. LPLs are derivatives of phospholipids and consist of a single hydrophobic fatty acid chain, a hydrophilic head, and a phosphate group with or without a large molecule attached.
Jing, Zhao, Yutong, Zhao
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Lysophospholipids in the nervous system
Prostaglandins & Other Lipid Mediators, 2005This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics ...
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Druggable Lysophospholipid Signaling Pathways
2020Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
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Lysophospholipid mediators of immunity and neoplasia
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and some other structurally related lysophospholipids are active growth factors and stimuli for diverse cellular functions. LPA and S1P promote early T cell migration to tissue sites of immune responses and regulate T cell proliferation and secretion of numerous cytokines.
Mei Chuan, Huang +4 more
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Chaperone-like Properties of Lysophospholipids
Biochemical and Biophysical Research Communications, 2001Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
R, Kern +3 more
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Lysophospholipid variants in hepatocellular carcinoma
Journal of Surgical Research, 2013The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill +5 more
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Lysophospholipid Receptors in the Nervous System
Neurochemical Research, 2002The lysophospholipid mediators, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), are responsible for cell signaling in diverse pathways including survival, proliferation, motility, and differentiation. Most of this signaling occurs through an eight-member family of G-protein coupled receptors once known as the endothelial differentiation ...
Rachelle E, Toman, Sarah, Spiegel
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