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Neuroprotection and activation of anti-inflammatory and plasticity mechanisms by PLC-β inhibition after cholinergic hyperstimulation in hippocampal slices and microglial cells. [PDF]
IBRO Neurosci RepPérez-Caraballo D +7 more
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Integrated transcriptomic, metabolomic and lipidomic analyses uncover the crucial roles of lipid metabolism pathways in oat (Avena sativa) responses to heat stress. [PDF]
BMC GenomicsSun Y +7 more
europepmc +1 more source
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Annual Review of Pharmacology and Toxicology, 2001
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate, produce many cellular effects. However, the prolonged absence of any cloned and identified LP receptor has left open the question of how these lipids actually bring about these effects.
N, Fukushima +4 more
openaire +3 more sources
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate, produce many cellular effects. However, the prolonged absence of any cloned and identified LP receptor has left open the question of how these lipids actually bring about these effects.
N, Fukushima +4 more
openaire +3 more sources
Lysophospholipids--Receptor Revelations
Science, 2001Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in ...
T, Hla +4 more
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Druggable Lysophospholipid Signaling Pathways
2020Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
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Lysophospholipids in Lung Inflammatory Diseases
2021The lysophospholipids (LPLs) belong to a group of bioactive lipids that play pivotal roles in several physiological and pathological processes. LPLs are derivatives of phospholipids and consist of a single hydrophobic fatty acid chain, a hydrophilic head, and a phosphate group with or without a large molecule attached.
Jing, Zhao, Yutong, Zhao
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Chaperone-like Properties of Lysophospholipids
Biochemical and Biophysical Research Communications, 2001Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
R, Kern +3 more
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Lysophospholipids as biosurfactants
Colloids and Surfaces, 1987Abstract Lysophospholipids are surface-active amphiphiles generated naturally in biological membranes by the action of phospholipases. These surfactants contain only one long chain fatty acyl group and therefore have much higher critical micelle concentrations than the parent phospholipids.
Richard E. Stafford, Edward A. Dennis
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Biological effects of lysophospholipids
2006Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
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