Results 181 to 190 of about 6,898 (217)

Chaperone-like Properties of Lysophospholipids

Biochemical and Biophysical Research Communications, 2001
Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
R, Kern, D, Joseleau-Petit, M K, Chattopadhyay, G, Richarme   +3 more
openaire   +2 more sources

Biological functions of bacterial lysophospholipids

2023
Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully ...
Cao, Xuefeng, van Putten, Jos P.M., Wösten, Marc M.S.M.   +2 more
openaire   +2 more sources

Lysophospholipid variants in hepatocellular carcinoma

Journal of Surgical Research, 2013
The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill, Wu, Jianmin, Xu, Yan, Zhenweng, Zhao, Alfred J, Tector, Mary A, Maluccio   +5 more
openaire   +2 more sources

Lysophospholipid Receptors in the Nervous System

Neurochemical Research, 2002
The lysophospholipid mediators, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), are responsible for cell signaling in diverse pathways including survival, proliferation, motility, and differentiation. Most of this signaling occurs through an eight-member family of G-protein coupled receptors once known as the endothelial differentiation ...
Rachelle E, Toman, Sarah, Spiegel
openaire   +2 more sources

Lysophospholipids are natriuretic and diuretic in rats

American Journal of Physiology-Renal Physiology, 1988
The effects of lysophosphatidylcholine (LPC) and some of its analogues on renal sodium (UNaV) and water excretion (V) were examined in the pentobarbital sodium-anesthetized rat. LPC caused the increase in UNaV and V with a steep dose response. The natriuretic effect began within 20 min after a bolus injection and lasted for 7 h.
A L, Rauch, V M, Buckalew
openaire   +2 more sources

Complexities of lysophospholipid signalling in glioblastoma

Journal of Clinical Neuroscience, 2014
Glioblastoma multiforme (GBM) is the most malignant brain tumour and continues to have a very poor median survival of 12-16 months despite current best therapies. These aggressive tumours always recur after treatment and are defined by their ability to diffusely infiltrate and invade normal brain parenchyma.
Wayne, Ng, Alice, Pébay, Katharine, Drummond, Antony, Burgess, Andrew H, Kaye, Andrew, Morokoff   +5 more
openaire   +2 more sources

Lysophospholipid Receptors: Signaling and Biology

Annual Review of Biochemistry, 2004
▪ Abstract  Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii, Nobuyuki, Fukushima, Xiaoqin, Ye, Jerold, Chun   +3 more
openaire   +2 more sources

Lysophospholipid receptors in cell signaling

Biochemistry (Moscow), 2007
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors.
T I, Torkhovskaya, O M, Ipatova, T S, Zakharova, M M, Kochetova, E M, Khalilov   +4 more
openaire   +2 more sources

Interactions of lysophospholipids and mast cells

Nature, 1979
PHOSPHOLIPID and protein are the major components of biological membranes, and much is known about their organisation in various cell membranes1,2. An important question concerns the existence and significance of specific protein–phospholipid interactions in membranes.
T W, Martin, D, Lagunoff
openaire   +2 more sources

Chemical approaches to the lysophospholipid receptors

Prostaglandins & Other Lipid Mediators, 2005
Both ligand-based and GPCR privileged scaffold chemical tools have recently emerged to provide new insights into the function and physiology of the GPCR lysophospholipid receptors both in vitro and in vivo. Both rational, design-based approaches as well as hybrid approaches where high throughput screening has been coupled to an understanding of ...
openaire   +2 more sources