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Lysophospholipids--Receptor Revelations
Science, 2001Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in ...
T, Hla +4 more
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Lysophospholipids in Lung Inflammatory Diseases
2021The lysophospholipids (LPLs) belong to a group of bioactive lipids that play pivotal roles in several physiological and pathological processes. LPLs are derivatives of phospholipids and consist of a single hydrophobic fatty acid chain, a hydrophilic head, and a phosphate group with or without a large molecule attached.
Jing, Zhao, Yutong, Zhao
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Lysophospholipids as biosurfactants
Colloids and Surfaces, 1987Abstract Lysophospholipids are surface-active amphiphiles generated naturally in biological membranes by the action of phospholipases. These surfactants contain only one long chain fatty acyl group and therefore have much higher critical micelle concentrations than the parent phospholipids.
Richard E. Stafford, Edward A. Dennis
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Mechanisms of cardioprotection by lysophospholipids
Journal of Cellular Biochemistry, 2004AbstractThe lysophospholipids sphingosine 1‐phosphate (S1P) and lysophosphosphatidic acid (LPA) reduce mortality in hypoxic cardiac myocytes. S1P is also cardioprotective in both mouse and rat models of cardiac ischemia/reperfusion (I/R) injury. Although these results are consistent with prior work in other cell types, it is not known what signaling ...
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Lysophospholipids and the cardiovascular system
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis. These molecules may exert potentially detrimental effects.
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Biological effects of lysophospholipids
2006Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
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Lysophospholipids as Mediators of Immunity
2006Lysophospholipids (LPLs) are lipid-derived signaling molecules exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Originally identified as serum-associated growth factors, these mediators now are known to signal through a family of diverse G protein-coupled receptors (GPCRs). Virtually all cells that participate in the immune
Debby A, Lin, Joshua A, Boyce
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Druggable Lysophospholipid Signaling Pathways
2020Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
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Lysophospholipid mediators of immunity and neoplasia
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and some other structurally related lysophospholipids are active growth factors and stimuli for diverse cellular functions. LPA and S1P promote early T cell migration to tissue sites of immune responses and regulate T cell proliferation and secretion of numerous cytokines.
Mei Chuan, Huang +4 more
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Lysophospholipids in the nervous system
Prostaglandins & Other Lipid Mediators, 2005This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics ...
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