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Biological functions of bacterial lysophospholipids
2023Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully ...
Cao, Xuefeng +2 more
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Lysophospholipid variants in hepatocellular carcinoma
Journal of Surgical Research, 2013The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill +5 more
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Lysophospholipid Receptors: Signaling and Biology
Annual Review of Biochemistry, 2004▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii +3 more
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Towards selective lysophospholipid GPCR modulators
Trends in Pharmacological Sciences, 2014G-protein-coupled receptors (GPCRs) that recognize the lysophospholipids (LPLs) are grouped into two phylogenetically distinct families: the endothelial differentiation gene (Edg) and non-Edg GPCRs. Owing to their more recent identification, and hindered by a lack of selective pharmacological tools, our understanding of the functions and signaling ...
Archbold, Julia K. +2 more
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Lysophospholipid receptors in cell signaling
Biochemistry (Moscow), 2007There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors.
T I, Torkhovskaya +4 more
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Lysophospholipids and the cardiovascular system
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis. These molecules may exert potentially detrimental effects.
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Stem cell regulation by lysophospholipids
Prostaglandins & Other Lipid Mediators, 2007Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range of mammalian cell processes, largely through engaging multiple G protein-coupled receptors specific for these lysophospholipids. LPA and S1P have been clearly identified to have widespread physiological and pathophysiological actions, controlling events within the ...
Pebay, A., Bonder, C., Pitson, S.
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Mechanisms of cardioprotection by lysophospholipids
Journal of Cellular Biochemistry, 2004AbstractThe lysophospholipids sphingosine 1‐phosphate (S1P) and lysophosphosphatidic acid (LPA) reduce mortality in hypoxic cardiac myocytes. S1P is also cardioprotective in both mouse and rat models of cardiac ischemia/reperfusion (I/R) injury. Although these results are consistent with prior work in other cell types, it is not known what signaling ...
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Lysophospholipid Acylation in RBC.
Blood, 2006AbstractThe formation, distribution and utilization of acyl-CoA plays a crucial role in plasma membrane phospholipid turnover in red blood cells (RBC). Upon de-acylation of glycero-phospholipids (PL) via the action of phospholipase, re-acylation of the lysophospholipids (LPL) requires activity of two enzymes of the Lands pathway.
Eric Soupene, Frans A. Kuypers
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Lysophospholipids in the nervous system
Prostaglandins & Other Lipid Mediators, 2005This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics ...
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