Results 91 to 100 of about 686,065 (200)

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Cell Reports
Summary: How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that primary microglial cells create acidic extracellular compartments, lysosomal synapses, on model
Rudy G. Jacquet, Fernando González Ibáñez, Katherine Picard, Lucy Funes, Mohammadparsa Khakpour, Gunnar K. Gouras, Marie-Ève Tremblay, Frederick R. Maxfield, Santiago Solé-Domènech   +8 more
doaj   +1 more source

Vincamine TPS activity on glycoconjugate metabolism of the brain: effect on lysosomal enzymes

, 1984
The effect of vincamine TPS intraperitoneal injection on brain lysosomal enzyme activity is reported. After acute drug administration, an activation of almost all enzymes was found, confirming the "vasometabolic" effect of this ...
D'Amore, I., Federico, A.
core  

Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains

, 2009
The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor participates in the trafficking of lysosomal enzymes from the trans-Golgi network or the cell surface to lysosomes.
Phinney, A. L., Scott, C. D., Hawkes, C., Mount, H. T., Amritraj, A., Westaway, D., Kar, S.   +6 more
core   +1 more source

Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.

, 1996
Azithromycin accumulates in lysosomes where it causes phospholipidosis. In homogenates prepared by sonication of fibroblasts incubated for 3 days with azithromycin (66 microM), the activities of sulfatase A, phospholipase A1, N-acetyl-beta-hexosaminidase
Paul M. Tulkens, Van Bambeke, Françoise, Jocelyne Piret, Gerbaux, C, Cécile Gerbaux, Tulkens, Paul M., Piret, J., Grégory Morlighem, Jean-Pierre Montenez, Françoise Van Bambeke, Montenez, J P, Morlighem, G   +11 more
core   +1 more source

Evidence of Lysosomal β-Hexosaminidase Enzymatic Activity Associated with Extracellular Vesicles: Potential Applications for the Correction of Sandhoff Disease

Journal of Functional Biomaterials
Extracellular vesicles (EVs) can be isolated from biological fluids and cell culture medium. Their nanometric dimension, relative stability, and biocompatibility have raised considerable interest for their therapeutic use as delivery vehicles of ...
Eleonora Calzoni, Giada Cerrotti, Krizia Sagini, Federica Delo, Sandra Buratta, Roberto Maria Pellegrino, Husam B. R. Alabed, Federica Fratini, Carla Emiliani, Lorena Urbanelli   +9 more
doaj   +1 more source

A binding protein for lysosomal enzymes isolated from brain by Phosphomannan-Sepharose chromatography

, 1983
We have isolated from monkey (Macaca radiata) brain lysosomal fraction by phosphomannan-Sepharose chromatography a protein that binds four different lysosomal enzymes, β-hexo-saminidase, β-glucuronidase, α-L-fucosidase and arylsulfatase.
Balasubramanian, A. S., Alvares, Keith
core   +1 more source

Lysosomal exoglycosidases as biomarkers of systemic diseases – what’s new?

Frontiers in Molecular Biosciences
Numerous studies suggest that lysosomal exoglycosidases can be utilised in the diagnosis and monitoring of various diseases. This paper summarises recent reports on the clinical use of N-acetyl-β-D-hexosaminidase (HEX), β-glucuronidase (GLU), β ...
Iwona Ptaszyńska-Sarosiek, Weronika Wiktoria Sarosiek, Gabriela Iga Sarosiek, Anna Charuta, Mateusz Maciejczyk   +4 more
doaj   +1 more source

Amelioration of Rheumatoid Arthritis by Anacardium occidentale via Inhibition of Collagenase and Lysosomal Enzymes. [PDF]

Evid Based Complement Alternat Med, 2020
Naz R, Ahmed Z, Shahzad M, Shabbir A, Kamal F.   +4 more
europepmc   +1 more source

Alteration of Lysosomal Membrane and Enzymes Induced by Peptidoglycan Monomer (PGM) [PDF]

, 1995
The inñuence of single (4 mg/mouse) and multiple (1 mg/mouse/day for 5 consecutive days) injections of PGM on some hepatic enzymes, lipid peroxide generation in serum and liver and hepatic lysosomal membrane permeability was investigated.
Marotti, Tatjana, Lipovac, Vaskresenija, Hršak, Ivo, Gavella, Mirjana, Šverko, Višnja   +4 more
core  

Spondyloepimetaphyseal dysplasia with elevated plasma lysosomal enzymes caused by homozygous variant in MBTPS1. [PDF]

Am J Med Genet A, 2020
Carvalho DR, Speck-Martins CE, Brum JM, Ferreira CR, Sobreira NLM.   +4 more
europepmc   +1 more source