Results 71 to 80 of about 89,565 (294)
Mr 46 000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes [PDF]
, 1987 Antibodies that block the ligand binding site of the cationdependent mannose 6-phosphate specific receptor (Mr 46 000 MIPR) were used to probe the function of the receptor in transport of lysosomal enzymes.
Stein, Martin +4 more
core
Data in Brief, 2016 In this data article we provide a detailed standard operating procedure for performing a tandem mass spectrometry, multiplex assay of 6 lysosomal enzymes for newborn screening of the lysosomal storage diseases Mucopolysaccharidosis-I, Pompe, Fabry ...
Susan Elliott +11 more
doaj +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
AUTOIMMUNITY TO LYSOSOMAL-ENZYMES - NEW CLUES TO VASCULITIS AND GLOMERULONEPHRITIS [PDF]
, 1991 The demonstration of autoantibodies to neutrophil cytoplasmic antigens (ANCA) in (1) systemic vasculitides such as Wegner's granulomatosis, classic polyarteritis nodosa and the Churg Strauss syndrome and (2) idiopathic crescentic glomerulonephritis has ...
WEENING, JJ +5 more
core +1 more source
Antioxidants, 2022 Physical activity has a positive effect on human health and well-being, but intense exercise can cause adverse changes in the organism, leading to the development of oxidative stress and inflammation.
Marta Pawłowska +8 more
doaj +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
A binding protein for lysosomal enzymes isolated from brain by Phosphomannan-Sepharose chromatography [PDF]
, 1983 We have isolated from monkey (Macaca radiata) brain lysosomal fraction by phosphomannan-Sepharose chromatography a protein that binds four different lysosomal enzymes, β-hexo-saminidase, β-glucuronidase, α-L-fucosidase and arylsulfatase.
Balasubramanian, A. S., Alvares, Keith
core +1 more source
Papain-like peptidases: structure, function, and evolution
Biomolecular Concepts, 2013 Papain-like cysteine peptidases are a diverse family of peptidases found in most known organisms. In eukaryotes, they are divided into multiple evolutionary groups, which can be clearly distinguished on the basis of the structural characteristics of the ...
Novinec Marko, Lenarčič Brigita
doaj +1 more source
High lumenal chloride in the lysosome is critical for lysosome function
eLife, 2017 Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases.
Kasturi Chakraborty +2 more
doaj +1 more source