Results 161 to 170 of about 929 (218)
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
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Advanced Science, EarlyView.Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen +14 more
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Chromatography of lysosomal enzymes
Archives of Biochemistry and Biophysics, 1968Abstract The soluble fraction of rat liver lysosomes has been chromatographed on DEAE-cellulose, Sephadex G-200, and CM-cellulose. Not all of the lysosomal enzymes measured were separated by chromatography on DEAE-cellulose or Sephadex G-200, although separation into groups of enzymes was possible. CM-cellulose chromatography gave the best resolution.
C, Beck +4 more
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Lysosomes, Lysosomal Enzymes, and Cancer
1992Publisher Summary Lysosomes are membrane-enclosed cytoplasmic organelles, which posses an acidic interior that contains many hydrolytic enzymes. Their major function is in the the degradation of macromolecules, which may be cellular or foreign in origin.
M J, Boyer, I F, Tannock
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Lysosomal enzymes in subretinal fluid
Albrecht von Graefes Archiv f�r Klinische und Experimentelle Ophthalmologie, 1976Samples of subretinal fluid (SRF) from patients with primary rhegmatogeneous retinal detachment of various duration were studied using standard enzymologic techniques. The protein content in SRF increased with the duration of detachment. The activities of lysosomal enzymes in SRF, which were acid phosphatase, beta-glucuronidase, and cathepsin D, also ...
S, Hayasaka, S, Hara, K, Mizuno
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Antigen catabolism by lysosomal enzymes
Immunochemistry, 1970Abstract The antigenicity of eight proteins (gelatin, insulin, hemoglobin, egg albumin, human γ-globulin, bovine serum albumin, keyhole limpet hemocyanin (KLH), and tetanus toxin) was compared by quantitative precipitin tests. Degradation of these proteins by lysosomal cathepsins in vitro was measured by estimation of the total amino acids released ...
W L, Ryan, J W, Lee
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Biochemical Society Transactions, 1990
Historical overview I want to express my appreciation to the Biochemical Society for having invited me to deliver the 1989 Jubilee Lecture. It is truly a great honour. The word Jubilee connotes a very special anniversary, and in this spirit I want to impart an historical overview to the Lecture in addition to reviewing my most recent work.
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Historical overview I want to express my appreciation to the Biochemical Society for having invited me to deliver the 1989 Jubilee Lecture. It is truly a great honour. The word Jubilee connotes a very special anniversary, and in this spirit I want to impart an historical overview to the Lecture in addition to reviewing my most recent work.
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Lysosomal Enzyme Abnormalities in Keratoconus
Archives of Ophthalmology, 1989We studied the lysosomal enzyme activities in corneas obtained from 12 patients with keratoconus. Three acid hydrolases--acid phosphatase, acid esterase, and acid lipase--were demonstrated by histochemical staining methods in the epithelium, stroma, and endothelium of corneas with keratoconus and normal human corneas.
S, Sawaguchi +3 more
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Lysosomal enzymes in human platelets
Cell Biochemistry and Function, 1985AbstractIn human freshly prepared platelets the following lysosomal enzymes were studied: α‐mannosidase, α‐fucosidase, β‐galactosidase, β‐glucosidase, β‐glucuronidase, β‐N‐acetylglucosaminidase and acid phosphatase. For each of the examined enzymes the conditions providing maximal activity (pH, buffer), kinetic parameters (saturating substrate ...
G, Leoncini, F, Balestrero, M, Maresca
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Lysosomal enzymes in cerebral atrophy
Clinica Chimica Acta, 1976In seven patients with cerebral atrophy due to pre-senile dementia and/or cerebrovascular disease, the activity of acid phosphatase in lumbar cerebrospinal fluid (CSF) was higher (p less than 0.05) than in six controls. The activity of arylsulphatase and beta-galactosidase in CSF was the same in the two groups.
C M, Yates +4 more
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