Results 51 to 60 of about 249,586 (383)
, 2007 Senescence in flower petals can be regarded as a form of programmed cell death (PCD), being a process where cells or tissues are broken down in an orderly and predictable manner, whereby nutrients are re-used by other cells, tissues or plant parts.
Cuervo, Ana Maria +5 more
core +6 more sources
Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis
Nature, 2018 Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and dysfunction of both organelles has been observed in multiple diseases.
Y. Wong, Daniel Ysselstein, D. Krainc
semanticscholar +1 more source
British Journal of Pharmacology, 2020 Cancer cells exhibit more dependence on iron and enhanced sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells. Quercetin exerts anti‐cancer effects, but the underlying molecular mechanism is largely unknown. In this study,
Zi-Xuan Wang +9 more
semanticscholar +1 more source
Screening of four lysosome-related genes in sepsis based on RNA sequencing technology
BMC Immunology, 2023 Purpose Screening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 patients diagnosed with sepsis and 10 normal controls for the purpose of RNA ...
Guihong Chen +5 more
doaj +1 more source
Nanodrugs Detonate Lysosome Bombs
Frontiers in Pharmacology, 2022 Cancer cell lysosomes contain various hydrolases and non-degraded substrates that are corrosive enough to destroy cancer cells. However, many traditional small molecule drugs targeting lysosomes have strong side effects because they cannot effectively ...
Yuting Xiang +20 more
doaj +1 more source
The role of lysosome in regulated necrosis
Acta Pharmaceutica Sinica B, 2020 Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention.
Aqu Alu +5 more
doaj +1 more source
Nature Communications, 2021 Mitochondrial division is not an autonomous event but involves multiple organelles, including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the constriction of mitochondrial membranes, the role of lysosomes in mitochondrial division
Maxime Boutry, P. Kim
semanticscholar +1 more source
Lysosomes, Lysosomal Storage Diseases, and Inflammation [PDF]
Journal of Inborn Errors of Metabolism and Screening, 2016 Lysosomes were originally described in the early 1950s by de Duve who was also the first to recognize the importance of these organelles in human disease. We know now that lysosomes are involved in numerous biological processes, and abnormalities in lysosomal function may result in a broad range of diseases. This review will briefly discuss the role of
openaire +5 more sources
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]
, 2013 BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Bartlett, NW +9 more
core +2 more sources
New insights regarding SNARE proteins in autophagosome-lysosome fusion
Autophagy, 2020 Macroautophagy/autophagy refers to the engulfment of cellular contents selected for lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the lysosome, which is mediated by SNARE proteins.
Xiaoyu Tian, J. Teng, Jianguo Chen
semanticscholar +1 more source