Results 11 to 20 of about 26 (25)

Modeling compartmentalization within intracellular signaling pathway [PDF]

arXiv, 2023
We present a new modeling approach for G protein coupled receptors signaling systems, that take into account the compartmentalization of receptors and their effectors, both at plasma membrane and in dynamic intra-cellular vesicles called endosomes. The first building block of the model is about compartment dynamics. It takes into account creation of de-
arxiv  

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease [PDF]

EBioMedicine, Elsevier, 2016, 9, pp.278-292, 2019
Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amy-loid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unraveled a 50% decrease in ADAM30 expression that ...
arxiv   +1 more source

Nucleus may be the key site of chloroquine antimalarial action and resistance development [PDF]

arXiv, 2017
The first proposed hypothesis about the mechanism of chloroquine (CQ) action on malaria parasites is DNA intercalation hypothesis which indicates that the site of CQ action is within the nucleus. Later on the interest of research was shifted from nucleus to lysosome due to the report of CQ accumulation within lysosome.
arxiv  

Effects of nanoparticles on murine macrophages [PDF]

, 2011
Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated. This requires to increase our knowledge of the cellular responses to nanoparticles. In this context, macrophages appear as
arxiv   +1 more source

Observation of Multiphoton-induced Fluorescence from Nano Graphene Oxide and Its Applications in In vitro and In vivo Bioimaging [PDF]

arXiv, 2012
In the present paper, we observed both two-photon and three-photon induced distinct photoluminescence from GO nanoparticles under fs laser excitation. Conjugated with PEG molecules, GO nanoparticles exhibited high chemical stability, and could effectively label HeLa cells.
arxiv  

Cell bystander effect induced by radiofrequency electromagnetic fields and magnetic nanoparticles [PDF]

arXiv, 2015
Induced effects by direct exposure to ionizing radiation (IR) are a central issue in many fields like radiation protection, clinic diagnosis and oncological therapies. Direct irradiation at certain doses induce cell death, but similar effects can also occur in cells no directly exposed to IR, a mechanism known as bystander effect.
arxiv  

A single-cell RNA expression map of coronavirus receptors and associated factors in developing human embryos [PDF]

arXiv, 2020
To predict if developing human embryos are permissive to coronaviruses, we analyzed publicly available single cell RNA-seq datasets of zygotes, 4-cell, 8-cell, morula, inner cell mass, epiblast, primitive endoderm and trophectoderm for the coronavirus receptors (ACE2, BSG, DPP4 and ANPEP), the Spike protein cleavage enzymes (TMPRSS2, CTSL).
arxiv  

In vivo mapping organellar metabolism by optical-boxcar enhanced fluorescence-detected mid-infrared photothermal microscopy [PDF]

arXiv
Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal transduction, cellular homeostasis, and organismal physiopathology. Despite the significance of lysosomal metabolism, a method for its in vivo measurement is currently lacking ...
arxiv  

Instant determination of the potential biomarker heparan sulfate in human plasma by a mix-and-read fluorescence assay [PDF]

arXiv, 2017
Heparan sulfate (HS) is a linear, polydisperse sulfated polysaccharide belonging to the glycosaminoglycan family. HS proteoglycans are ubiquitously found at the cell surface and extracellular matrix in animal species. HS is involved in the interaction with a wide variety of proteins and the regulation of many biological activities.
arxiv  

Targeting C99 Mediated Metabolic Disruptions with Ketone Therapy in Alzheimer's Disease [PDF]

arXiv
The role of ketone bodies in Alzheimers disease (AD) remains incompletely understood, particularly regarding their influence on amyloid pathology. While beta}hydroxybutyrate (BHB) has been implicated in neuroprotection, direct evidence for its effects on amyloid beta(Abeta) deposition, aggregation, or clearance is lacking. Furthermore, whether BHB acts
arxiv