Results 11 to 20 of about 231,146 (358)

Switching on lysosomes

eLife
The formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
openaire   +4 more sources

An annotated high-content fluorescence microscopy dataset with Hoechst 33342-stained nuclei and manually labelled outlines

Data in Brief, 2023
Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as ...
Malou Arvidsson, Salma Kazemi Rashed, Sonja Aits   +2 more
doaj   +1 more source

Branching Off: New Insight Into Lysosomes as Tubular Organelles

Frontiers in Cell and Developmental Biology, 2022
Lysosomes are acidic, membrane-bound organelles that play essential roles in cellular quality control, metabolism, and signaling. The lysosomes of a cell are commonly depicted as vesicular organelles.
K. Adam Bohnert, Alyssa E. Johnson
doaj   +1 more source

Penicillin kills chlamydia following the fusion of bacteria with Lysosomes and prevents genital inflammatory lesions in C. muridarum-infected mice [PDF]

, 2013
The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion ...
Delarbre, C., Dumoux, Maud, Habbeddine, M., Hayward, Richard D., Kanellopoulos-Langevin, C., Le Gall, S.M., Ramsey, K., Verbeke, P.   +7 more
core   +14 more sources

Super‐resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

Exploration, 2022
Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome subpopulations with dynamics and characteristic cellular localization.
Lei Wang, Rui Chen, Guanqun Han, Xuan Liu, Taosheng Huang, Jiajie Diao, Yujie Sun   +6 more
doaj   +1 more source

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

Frontiers in Pharmacology, 2021
Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes.
Marie Tautou, Sabiha Eddarkaoui, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Jamal El Bakali, Liesel Mary Goveas, Mélanie Dumoulin, Chloé Lamarre, David Blum, David Blum, Luc Buée, Luc Buée, Patricia Melnyk, Nicolas Sergeant, Nicolas Sergeant   +15 more
doaj   +1 more source

CMTM6-Deficient Monocytes in ANCA-Associated Vasculitis Fail to Present the Immune Checkpoint PD-L1

Frontiers in Immunology, 2021
ObjectivesANCA-associated vasculitides (AAV) affect small- and medium-sized blood vessels. In active disease, vessel wall infiltrates are mainly composed of monocytes and macrophages.
Markus Zeisbrich, Nina Chevalier, Bettina Sehnert, Marta Rizzi, Nils Venhoff, Jens Thiel, Reinhard E. Voll   +6 more
doaj   +1 more source

Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies. [PDF]

Front Cell Infect Microbiol
Tuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Bao C, Zhang Y, Feng J, Hong X, Gao N, Feng G.   +5 more
europepmc   +2 more sources

Functions of lysosomes in mammalian female reproductive system

Reproductive and Developmental Medicine, 2020
The lysosome is the most acidic membrane-bound intracellular organelle. Lysosomal acidity is primarily maintained by vacuolar H+-ATPase (V-ATPase) and counter ion channels.
Yuehuan Li, Zidao Wang, Christian L Andersen, Xiaoqin Ye   +3 more
doaj   +1 more source

The role of lysosomes in cancer development and progression

Cell & Bioscience, 2020
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release,
Tao Tang, Ze-yu Yang, Di Wang, Xian-yan Yang, Jun Wang, Lin Li, Qian Wen, Lei Gao, Xiu-wu Bian, Shi-cang Yu   +9 more
doaj   +1 more source