Results 41 to 50 of about 231,146 (358)

Development of targeted therapies for Parkinson's disease and related synucleinopathies

Journal of Lipid Research, 2014
Therapeutic efforts in neurodegenerative diseases have been very challenging, particularly due to a lack of validated and mechanism-based therapeutic targets and biomarkers. The basic idea underlying the novel therapeutic approaches reviewed here is that
Edmund Sybertz, Dimitri Krainc
doaj   +1 more source

Cancer: Linking Powerhouses to Suicidal Bags

Frontiers in Oncology, 2017
Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense.
Laia Martinez-Carreres, Anita Nasrallah, Lluis Fajas   +2 more
doaj   +1 more source

The Exploitation of Lysosomes in Cancer Therapy with Graphene-Based Nanomaterials

Pharmaceutics, 2023
Graphene-based nanomaterials (GNMs), including graphene, graphene oxide, reduced graphene oxide, and graphene quantum dots, may have direct anticancer activity or be used as nanocarriers for antitumor drugs.
Biljana Ristic, Mihajlo Bosnjak, Maja Misirkic Marjanovic, Danijela Stevanovic, Kristina Janjetovic, Ljubica Harhaji-Trajkovic   +5 more
doaj   +1 more source

Rag GTPases are cardioprotective by regulating lysosomal function. [PDF]

, 2014
The Rag family proteins are Ras-like small GTPases that have a critical role in amino-acid-stimulated mTORC1 activation by recruiting mTORC1 to lysosome.
Guan, Kun-Liang, Jewell, Jenna L, Kim, Young Chul, Mo, Jung-Soon, Park, Hyun Woo, Russell, Ryan C, Sadoshima, Junichi, Sciarretta, Sebastiano, Wu, Xiaohui   +8 more
core   +6 more sources

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates [PDF]

, 2018
Nitrogen-containing-bisphosphonates (N-BPs) are widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which
Abu-Remaileh, Monther, Horlbeck, Max A, O\u27Shea, Erin K, Park, Chong Yon, Peterson, Timothy R, Sabatini, David M, Surface, Lauren E, Weissman, Jonathan S, Wyant, Gregory A, Yu, Zhou   +9 more
core   +3 more sources

Lysosomes, Lysosomal Storage Diseases, and Inflammation [PDF]

Journal of Inborn Errors of Metabolism and Screening, 2016
Lysosomes were originally described in the early 1950s by de Duve who was also the first to recognize the importance of these organelles in human disease. We know now that lysosomes are involved in numerous biological processes, and abnormalities in lysosomal function may result in a broad range of diseases. This review will briefly discuss the role of
openaire   +5 more sources

Autophagy-Associated IL-15 Production Is Involved in the Pathogenesis of Leprosy Type 1 Reaction

Cells, 2021
Leprosy reactional episodes are acute inflammatory events that may occur during the clinical course of the disease. Type 1 reaction (T1R) is associated with an increase in neural damage, and the understanding of the molecular pathways related to T1R ...
Bruno Jorge de Andrade Silva, Tamiris Lameira Bittencourt, Thyago Leal-Calvo, Mayara Abud Mendes, Rhana Berto da Silva Prata, Mayara Garcia de Mattos Barbosa, Priscila Ribeiro Andrade, Suzana Côrte-Real, Gilberto Marcelo Sperandio da Silva, Milton Ozório Moraes, Euzenir Nunes Sarno, Roberta Olmo Pinheiro   +11 more
doaj   +1 more source

An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlineszenodo

Data in Brief
Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be ...
Salma Kazemi Rashed, Malou Arvidsson, Rafsan Ahmed, Sonja Aits   +3 more
doaj   +1 more source

Lysosomal Functions in Glia Associated with Neurodegeneration

Biomolecules, 2021
Lysosomes are cellular organelles that contain various acidic digestive enzymes. Despite their small size, they have multiple functions. Lysosomes remove or recycle unnecessary cell parts. They repair damaged cellular membranes by exocytosis.
Conlan Kreher, Jacob Favret, Malabika Maulik, Daesung Shin   +3 more
doaj   +1 more source

Glutamate induces autophagy via the two-pore channels in neural cells [PDF]

, 2016
NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
 , ,, Antonioli, M, Bincoletto, C, Fimia, G, Hirata, H, Nascimento, A, Pereira, G, Piacentini, M, Smaili, S, Ureshino, R, Vescovo, T   +11 more
core   +4 more sources