Results 41 to 50 of about 82,606 (197)

Autophagosome maturation: An epic journey from the ER to lysosomes

Journal of Cell Biology, 2018
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and their delivery to lysosomes for degradation. In multicellular organisms, nascent autophagosomes fuse with vesicles originating from endolysosomal ...
Yan G. Zhao, Hong Zhang
semanticscholar   +1 more source

Visualization of endogenous G proteins on endosomes and other organelles

eLife
Classical G-protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take
Wonjo Jang, Kanishka Senarath, Gavin Feinberg, Sumin Lu, Nevin A Lambert   +4 more
doaj   +1 more source

The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer

Journal of Lipid Research, 2021
In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9) were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a precursor (proPCSK9) that undergoes autocatalytic cleavage in the ...
Nabil G. Seidah
doaj   +1 more source

Exogenous Metabolic Modulators Improve Response to Carboplatin in Triple-Negative Breast Cancer

Cells
Triple-negative breast cancer (TNBC) lacks targeted therapies, leaving cytotoxic chemotherapy as the current standard treatment. However, chemotherapy resistance remains a major clinical challenge.
Alyssa N. Ho, Violet A. Kiesel, Claire E. Gates, Bennett H. Brosnan, Scott P. Connelly, Elaine M. Glenny, Alyssa J. Cozzo, Stephen D. Hursting, Michael Francis Coleman   +8 more
doaj   +1 more source

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

eLife, 2018
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts ...
Zhou Yu, Lauren E Surface, Chong Yon Park, Max A Horlbeck, Gregory A Wyant, Monther Abu-Remaileh, Timothy R Peterson, David M Sabatini, Jonathan S Weissman, Erin K O'Shea   +9 more
doaj   +1 more source

Dysfunctional Autophagy and Endolysosomal System in Neurodegenerative Diseases: Relevance and Therapeutic Options

Frontiers in Cellular Neuroscience, 2020
Autophagy and endolysosomal trafficking are crucial in neuronal development, function and survival. These processes ensure efficient removal of misfolded aggregation-prone proteins and damaged organelles, such as dysfunctional mitochondria, thus allowing
Silvia Giovedì, Silvia Giovedì, Margherita Maria Ravanelli, Margherita Maria Ravanelli, Barbara Parisi, Barbara Bettegazzi, Barbara Bettegazzi, Fabrizia Claudia Guarnieri, Fabrizia Claudia Guarnieri, Fabrizia Claudia Guarnieri   +9 more
doaj   +1 more source

Vesicular trafficking and cell-cell communication in neurodevelopment and neurodegeneration

Frontiers in Cell and Developmental Biology
Regulation of vesicle biology and trafficking plays a critical role in cell viability. Vesicular trafficking is a process that entails vesicle biogenesis, transport, and sorting of materials such as proteins, enzymes, hormones, and neurotransmitters to ...
Salma Amin, Elena Taverna
doaj   +1 more source

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance LRRK2, a protein kinase related to Parkinson’s disease, is implicated in the maintenance of lysosomes, and a subset of Rab GTPases has been identified as bona fide substrates of LRRK2. Here, we reveal a key stress-responsive pathway composed
T. Eguchi, Tomoki Kuwahara, Maria Sakurai, Tadayuki Komori, Tetta Fujimoto, Genta Ito, S. Yoshimura, A. Harada, M. Fukuda, Masato Koike, T. Iwatsubo   +10 more
semanticscholar   +1 more source

Lysosomal Storage Diseases

Translational Science of Rare Diseases, 2016
Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the accumulation of the material meant for lysosomal degradation. Examples include glycogen in the case of Pompe disease, glycosaminoglycans in the case of the mucopolysaccharidoses,
Ferreira, Carlos R., Gahl, William A.
openaire   +3 more sources

Functional Involvement of Carbonic Anhydrase in the Lysosomal Response to Cadmium Exposure in Mytilus galloprovincialis Digestive Gland

Frontiers in Physiology, 2018
Carbonic anhydrase (CA) is a ubiquitous metalloenzyme, whose functions in animals span from respiration to pH homeostasis, electrolyte transport, calcification, and biosynthetic reactions. CA is sensitive to trace metals in a number of species.
Roberto Caricato, M. Elena Giordano, Trifone Schettino, M. Giulia Lionetto   +3 more
doaj   +1 more source