Results 41 to 50 of about 239,873 (360)
Journal of Molecular Biology, 2020 Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes. The process starts with the capture of unnecessary material into autophagosomes, which is followed by autophagosome-lysosome fusion to generate autolysosomes that degrade the ...
Lőrincz, Péter, Juhász, Gábor
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eLifeThe formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
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PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis
Journal of Lipid Research, 2018 The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2].
Ao Hu +9 more
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Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles
Antioxidants, 2022 KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero +12 more
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Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. [PDF]
, 2017 Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML).
Arbiser, Jack L +6 more
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Bioimaging of Lysosomes with a BODIPY pH-Dependent Fluorescent Probe
Molecules, 2022 Fluorescence-based probes represent a powerful tool for noninvasive imaging of living systems in real time and with a high temporal and spatial resolution.
Raquel C. R. Gonçalves +7 more
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Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies
Frontiers in Cellular and Infection MicrobiologyTuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Cui Bao +10 more
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Cells, 2021 Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska +9 more
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European Journal of Biochemistry, 1983 The first international symposium on lysosomes [1] was held in 1963 at the Ciba Foundation, under the chairmanship of Danielli and with the participation of a prestigious membership. It is interesting to compare our present understanding of the properties and functions of lysosomes with what was known 20 years ago.
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Cytoplasmic Flow and Mixing Due to Deformation of Motile Cells. [PDF]
, 2017 The cytoplasm of a living cell is a dynamic environment through which intracellular components must move and mix. In motile, rapidly deforming cells such as human neutrophils, bulk cytoplasmic flow couples cell deformation to the transport and dispersion
Chan, Caleb K +2 more
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