Results 51 to 60 of about 231,146 (358)
Antioxidants, 2021 In this report, we evaluated the role of iron in sodium iodate (NaIO3)-induced model of age-related macular degeneration (AMD) in ARPE-19 cells in-vitro, and mouse models in-vivo.
Ajay Ashok +7 more
doaj +1 more source
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells. [PDF]
, 2017 Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML).
Arbiser, Jack L +6 more
core +1 more source
Journal of Extracellular Vesicles, 2023 Tumour cells under hypoxia tend to modulate the number and contents of extracellular vesicles (EVs) to regulate the tumour microenvironment (TME) and thus promote tumour progression.
Xiaoning Wang +10 more
doaj +1 more source
The Contribution of Lysosomes to DNA Replication
Cells, 2021 Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for
Joanna Maria Merchut-Maya +1 more
doaj +1 more source
The trafficking and targeting of P2X receptors [PDF]
, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D +1 more
core +3 more sources
Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
Medicines, 2021 Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance.
Reginald Halaby
doaj +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
Cells, 2018 Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms.
Bernhard Englinger +10 more
doaj +1 more source
Molecules, 2021 Amlodipine, a unique long-lasting calcium channel antagonist and antihypertensive drug, has weak fluorescence in aqueous solutions. In the current paper, we show that direct visualization of amlodipine in live cells is possible due to the enhanced ...
Christine Quentin +6 more
doaj +1 more source
Lysosomes and lysosome‐related organelles in immune responses [PDF]
FEBS Open Bio, 2022 The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms. From the ‘creative destruction’ of antigenic and ‘self’ material for antigen presentation to T cells to the re‐purposing of lysosomes as toxic exocytosable lysosome‐related ...
openaire +4 more sources