Results 81 to 90 of about 82,606 (197)

A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis. [PDF]

, 1990
R.L. Pisoni, T L Acker, Karen M Lisowski, Rosemary Lemons, Jess G. Thoene   +4 more
openalex   +1 more source

Lysosomes [PDF]

Nature Biotechnology, 2020
openaire   +2 more sources

Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy

Cells
Lysosomes are subcellular compartments characterised by an acidic pH, containing an ample variety of acid hydrolases involved in the recycling of biopolymers.
Ryan Conesa-Bakkali, Macarena Morillo-Huesca, Jonathan Martínez-Fábregas   +2 more
doaj   +1 more source

Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines

Neuron, 2017
Summary Lysosomes have traditionally been viewed as degradative organelles, although a growing body of evidence suggests that they can function as Ca2+ stores. Here we examined the function of these stores in hippocampal pyramidal neurons.
Zahid Padamsey, L. McGuinness, Scott J. Bardo, Marcia Reinhart, Rudi Tong, A. Hedegaard, Michael L. Hart, N. Emptage   +7 more
semanticscholar   +1 more source

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines

Journal of Cell Biology, 2017
In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily reside in somatic and axonal compartments, but there is little understanding of their distribution and function in dendrites.
Marisa S Goo, L. Sancho, Natalia Slepak, D. Boassa, T. Deerinck, Mark Ellisman, Brenda L. Bloodgood, G. Patrick   +7 more
semanticscholar   +1 more source

Lysosome Functions in Atherosclerosis: A Potential Therapeutic Target

Cells
Lysosomes in mammalian cells are recognized as key digestive organelles, containing a variety of hydrolytic enzymes that enable the processing of both endogenous and exogenous substrates.
Zhengchao Wang, Xiang Li, Alexandra K. Moura, Jenny Z. Hu, Yun-Ting Wang, Yang Zhang   +5 more
doaj   +1 more source

Lysosomes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Gieselmann, Volkmar, Braulke, Thomas
openaire   +3 more sources

Preferential ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux from Late Endosomes/Lysosomes [PDF]

, 2001
Wengen Chen, Yu Sun, Carrie L. Welch, Anna Gorelik, Andrew Leventhal, Ira Tabas, Alan R. Tall   +6 more
openalex   +1 more source

Phosphatidylinositol 3,5‐Bisphosphate‐Rich Membrane Domains in Endosomes and Lysosomes [PDF]

, 2015
Sho Takatori, Tsuyako Tatematsu, Jinglei Cheng, Jun Matsumoto, Takuya Akano, Toyoshi Fujimoto   +5 more
openalex   +1 more source

Lysosome‐autophagosome defects mediate proteinopathy in early stages of Alzheimer’s disease [PDF]

, 2020
Sarah H Mustaly, Kenneth D. Beaman, Alice Gilman‐Sachs, Sean Schrank, Robert A. Marr, Grace E. Stutzmann   +5 more
openalex   +1 more source