Results 101 to 110 of about 228,048 (263)

Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles [PDF]

, 2011
The nuclear membrane is one of the major cellular barriers in the delivery of plasmid DNA (pDNA). Cell division has a positive influence on the expression efficiency since, at the end of mitosis, pDNA or pDNA containing complexes near the chromatin are ...
De Smedt, Stefaan, Demeester, Jo, Mattaj, Iain, Remaut, Katrien, Symens, Nathalie, Walczak, Rudolf   +5 more
core   +1 more source

Organelle Localization‐Induced Bio‐Orthogonal Polymerization (OLIBOP) for Photostable Super‐Resolution Live‐Cell Imaging

Advanced Healthcare Materials, EarlyView.
Organelle localization‐induced biorthogonal polymerization enables direct synthesis of photostable poly‐AIEgens within targeted organelles for super‐resolution live‐cell imaging. ABSTRACT Real‐time monitoring of dynamic biological processes demands fluorescent probes that can withstand prolonged light exposure without photobleaching—a critical ...
Gaeun Park, Sangpil Kim, Dohyun Kim, Injun Hwang, Ja‐Hyoung Ryu   +4 more
wiley   +1 more source

Endolysosomal pathway activity protects cells from neurotoxic TDP-43

Microbial Cell, 2018
The accumulation of protein aggregates in neurons is a typical pathological hallmark of the motor neuron disease amyotrophic lateral sclerosis (ALS) and of frontotemporal dementia (FTD).
Christine Leibiger, Jana Deisel, Andreas Aufschnaiter, Stefanie Ambros, Maria Tereshchenko, Bert M. Verheijen, Sabrina Büttner, Ralf J. Braun   +7 more
doaj   +1 more source

Dual Role of Subphthalocyanine Dyes for Optical Imaging and Therapy of Cancer [PDF]

, 2018
This is the peer-reviewed version of the following article: van de Winckel, E., Mascaraque, M., Zamarrón, A., Juarranz de la Fuente, Á., Torres, T., & de la Escosura, A. (2018).
Escosura Navazo, Andrés de la, Juarranz de la Fuente, Ángeles, Mascaraque Checa, Marta, Torres Cebada, Tomás, van de Winckel, Eveline, Zamarrón, Alicia   +5 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Late Effects of Ionizing Radiation on the Ultrastructure of Hepatocytes and Activity of Lysosomal Enzymes in Mouse Liver Irradiated In Vivo

Metabolites
The study aimed to investigate late radiation-induced changes in the histology, ultrastructure, and activity of lysosomal enzymes in mouse liver exposed to ionizing radiation.
Małgorzata Łysek-Gładysińska, Anna Wieczorek, Anna Walaszczyk, Karol Jelonek, Monika Pietrowska, Piotr Widłak, Roland Kulik, Dorota Gabryś   +7 more
doaj   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

A β‐galactosidase activated near‐infrared fluorescent probe for tracking cellular senescence in vitro and in vivo

Smart Molecules
Cellular senescence is a steady state of cell cycle arrest necessary to maintain homeostasis in organisms. However, senescent cells may cause senescence in neighboring healthy cells, inducing the onset of several diseases, such as inflammation ...
Tian Su, Ruijun Shen, Dengchu Tu, Xiaoyue Han, Xianzhu Luo, Fabiao Yu   +5 more
doaj   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source