Results 101 to 110 of about 171,488 (262)

Incubation of cells with sucrose results in enlargement of lysosomes.

, 2014
(A) Confocal fluorescence microscopy image of untreated BS-C-1 cells shows the normal cellular distribution and punctate appearance of lysosomes (green) labeled with EYFP. The nuclei are stained with DAPI (blue). (B) Incubation with sucrose (50 mM, 12 h)
Jairo A. Zapata (518448), Y. Joseph Kim (518449), Austin Cyphersmith (518447), Debjyoti Bandyopadhyay (518446), Christine K. Payne (200122)   +4 more
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Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

The interactions of trialkyltin compounds with lysosomes from rat liver

, 1981
Interactions of two trialkyltin compounds with the lysosomes from a rat liver have been studied. It is shown that these compounds induce a fast alkalinisation in the matrix of energised lysosomes.
MARTON, DANIELE, Bragadin, M., DELL'ANTONE, PAOLO, SCUTARI, GUIDO, Ryan, Michael D., O. Maglio, Feinberg, Benjamin A., Shafran, KL, Marcantonio Bragadin, LOMBARDI, ANGELINA, E. Laurenti, W. DeGrado, NASTRI, FLAVIA, R. Ferrari, Enyedy, Éva Anna, MARASCO, DANIELA, L. Randaccio, Farkas, Etelka, Perry, CC, S. Geremia, Paolo Dell'Antone, Wei, Jing-Fong, Daniele Marton, L. Di Costanzo, Csóka, Hajnalka, Guido Scutari, PAVONE, VINCENZO   +26 more
core   +1 more source

Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy

Cells
Venetoclax and obinutuzumab are becoming frontline therapies for chronic lymphocytic leukemia (CLL) patients. Unfortunately, drug resistance still occurs, and the combination could be immunosuppressive.
Madhumita S. Manivannan, Xiaoyan Yang, Nirav Patel, Anthea Peters, James B. Johnston, Spencer B. Gibson   +5 more
doaj   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

REVERSIBLE ACTIVATION OF LYSOSOMES IN RAT LIVER

, 1965
Using the enzyme acid phosphatase as a marker for lysosomes, a histochemical study has been made of the effects of the operative procedure for partial hepatectomy upon the lysosomes of rat liver.
P. B. GAHAN
core   +1 more source

Lysosome targeted therapies in hematological malignancies

Frontiers in Oncology
Lysosomes are dynamic organelles integral to cellular homeostasis, secretory pathways, immune responses, and cell death regulation. In cancers, lysosomes become dysregulated to sustain proliferative signaling, metabolism, and invasion.
Madhumita S. Manivannan, Anthea Peters, Spencer B. Gibson   +2 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Lysosomes of rat liver and kidney.

, 1983
Fractionation techniques, based on zonal centrifugation in density gradients, were developed for examining the heterogeneity of lysosomal populations and also for the purification of lysosomes from normal rat liver.
Dobrota, Miloslav.
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