Results 101 to 110 of about 158,743 (267)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Interaction of rat liver lysosomes with basic polypeptides

, 1995
In order to gain knowledge on the interaction of lysosomes with proteins, we have assessed the equilibrium densities of the lysosomal membrane and matrix markers after in vitro incubation of rat liver lysosomes with various polypeptides.
Rukavishnikova, Elena V., Toshihiro Sassa, Tatjana A. Korolenko, Korolenko, Tatjana A., Horiuchi, Saburou, Oka, Tatsuzo, Sassa, Toshihiro, Saburou Horiuchi, Elena V. Rukavishnikova, Natoria, Yasuo, Tatsuzo Oka, Yasuo Natoria   +11 more
core   +1 more source

A β‐galactosidase activated near‐infrared fluorescent probe for tracking cellular senescence in vitro and in vivo

Smart Molecules
Cellular senescence is a steady state of cell cycle arrest necessary to maintain homeostasis in organisms. However, senescent cells may cause senescence in neighboring healthy cells, inducing the onset of several diseases, such as inflammation ...
Tian Su, Ruijun Shen, Dengchu Tu, Xiaoyue Han, Xianzhu Luo, Fabiao Yu   +5 more
doaj   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Lysosomes of rat liver and kidney.

, 1983
Fractionation techniques, based on zonal centrifugation in density gradients, were developed for examining the heterogeneity of lysosomal populations and also for the purification of lysosomes from normal rat liver.
Dobrota, Miloslav.
core  

Mechanisms of communication between mitochondria and lysosomes

, 2016
Mitochondria and lysosomes have long been studied in the context of their classic functions: energy factory and recycle bin, respectively. In the last twenty years, it became evident that these organelles are much more than simple industrial units, and ...
Fernandez-Mosquera, Lorena, Diogo, Catia V., Raimundo, Nuno, Yambire, King Faisal   +3 more
core   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Lysosomes of rat liver and kidney.

, 2018
Fractionation techniques, based on zonal centrifugation in density gradients, were developed for examining the heterogeneity of lysosomal populations and also for the purification of lysosomes from normal rat liver.
Dobrota, Miloslav.
core  

REVERSIBLE ACTIVATION OF LYSOSOMES IN RAT LIVER

, 1965
Using the enzyme acid phosphatase as a marker for lysosomes, a histochemical study has been made of the effects of the operative procedure for partial hepatectomy upon the lysosomes of rat liver.
P. B. GAHAN
core   +1 more source

Dual Acidic pH‐Responsive Post‐Crosslinked E‐Spun Nanofibrous Scaffolds Exhibiting Enhanced Disassembly and Release for Localized Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Dual acidic pH‐responsive degradable e‐spun nanofibrous mats crosslinked with acid‐labile imine and boronic ester linkages that exhibit rapid degradation and enhanced release of encapsulated anticancer drugs through their acid‐catalyzed hydrolysis and their doxorubicin‐loaded mats having desired antitumoral activity and hemocompatibility, as promising ...
Sofia Nieves Casillas‐Popova, Arianna Cirillo, Cameron D. Skinner, Dajana Vuckovic, Jung Kwon Oh   +4 more
wiley   +1 more source