Results 121 to 130 of about 171,488 (262)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

The unconventional myosin-VIIa associates with lysosomes.

, 2005
Mutations in the myosin-VIIa (MYO7a) gene cause human Usher disease, characterized by hearing impairment and progressive retinal degeneration. In the retina, myosin-VIIa is highly expressed in the retinal pigment epithelium, where it plays a role in the ...
SONI LE, BUCCI, Cecilia, AND HASSON T., WARREN CM, ORTEN DJ   +4 more
core  

The Remarkable Efficiency of Melanin Reduction by Using Functional Organelle, Lysosomes

, 2017
Lysosomes have reported that lysosomal intensity increased depending by aging. Lysosome and melanosome have some relations because melanosome has same producing pathway with lysosomes. Therefore we evaluated lysosomal intensity with efficiency of melanin
Jiho Min, Dong Jun Park, Yang-Hoon Kim
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Characterization of basal lysosomes in exocrine acinar cells.

, 1983
Exocrine acinar cells possess a unique system of basally located lysosomes. Cytochemically, these lysosomes do not contain acid phosphatase, but react positively for trimetaphosphatase (C Oliver: J Histochem Cytochem 28:78, 1980).
C Oliver
core   +1 more source

Studies on the breakdown of glycogen in the lysosomes: The effects of hydrocortisone [PDF]

, 2011
The effects of hydrocortisone on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry. Hydrocortisone increased the number of lysosomes in the hepatocytes. Most of the lysosomes represented glycogen-
Kalamidas, Stefanos A., Kotoulas, O. B.
core   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples [PDF]

Lysosomes are implicated in a wide spectrum of human diseases including monogenic lysosomal storage disorders (LSDs), age-associated neurodegeneration and cancer.
Cindy Lin, Enrico Bagnoli, Lamoliatte, Fred, Zunke, Friederike, Wentao Dong, Rotimi Fasimoye, Alessi, Dario; id_orcid, Matthew Jaconelli, Pawel Lis, Lin, Cindy, Raja S. Nirujogi, Friederike Zunke, Abu-Remaileh, Monther, van Hasselt, Peter M., Angela Schulz, Eshaan Rawat, Nyame, Kwamina, Elshani, Sadik, Zeneviciute, Karolina, Posern, Christian, Judith J.M. Jans, Sophie Glendinning, Peter M. van Hasselt, Glendinning, Sophie, Huisman, Margriet A., Nirujogi, Raja; id_orcid, Boros, Fanni A., Gomes, Sara; id_orcid, Jaconelli, Matthew, Margriet A. Huisman, Sammler, Esther; id_orcid, Monther Abu-Remaileh, Dario R. Alessi, Bagnoli, Enrico, Daniel Saarela, Esther M. Sammler, Dong, Wentao, Rawat, Eshaan S., Schulz, Angela, Fasimoye, Rotimi, Kwamina Nyame, Westermann, Lena M., Fanni A. Boros, Sadik Elshani, Sara Gomes, Jans, Judith J. M., Lis, Paweł; id_orcid, Saarela, Daniel, Lena M. Westermann, Karolina Zeneviciute, Frederic Lamoliatte, Christian Posern   +51 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source