Results 31 to 40 of about 116,909 (259)

Probing the interaction of lysozyme with cardiac glycoside digitoxin: experimental and in silico analyses

Frontiers in Molecular Biosciences, 2023
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali, Hamad A. Al-Lohedan, Rittik Bhati, Jayaraman Muthukumaran   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Clinical relevance of serum lysozyme in sarcoidosis with kidney impairment

Immunological Medicine
The clinical significance of serum lysozyme in sarcoidosis remains unclear. This study aimed to evaluate the clinical characteristics and kidney function of sarcoidosis patients with elevated serum lysozyme.
Shunichiro Hanai, Yoshiaki Kobayashi, Kojiro Ikeda, Soichiro Kubota, Nakako Tanaka-Mabuchi, Mayu Yazaki, Makiko Konishi, Kazuya Takahashi, Daiki Nakagomi   +8 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.

PLoS ONE, 2020
Many conflicting reports about the involvement of serum amyloid P component (SAP) in amyloid diseases have been presented over the years; SAP is known to be a universal component of amyloid aggregates but it has been suggested that it can both induce and
Liza Bergkvist, Daniel R Richards, Ana Bernardo-Gancedo, Janet R Kumita, Peter R Nilsson, Ann-Christin Brorsson   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Lysozyme Modification Using Proteolytic Enzymes

Molecules, 2023
The lysozyme in the chicken egg white consists of various bioactive amino acids. However, these compounds are inactive when they are in the sequence of parent proteins. They become active only when isolated from these proteins.
Łukasz Tomczyk, Grzegorz Leśnierowski, Renata Cegielska-Radziejewska   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Oral administration of lysozyme protects against injury of ileum via modulating gut microbiota dysbiosis after severe traumatic brain injury

Frontiers in Cellular and Infection Microbiology
ObjectiveThe current study sought to clarify the role of lysozyme-regulated gut microbiota and explored the potential therapeutic effects of lysozyme on ileum injury induced by severe traumatic brain injury (sTBI) and bacterial pneumonia in vivo and in ...
Weijian Yang, Weijian Yang, Weijian Yang, Weijian Yang, Weijian Yang, Caihua Xi, Caihua Xi, Caihua Xi, Caihua Xi, Caihua Xi, Haijun Yao, Haijun Yao, Haijun Yao, Haijun Yao, Haijun Yao, Qiang Yuan, Qiang Yuan, Qiang Yuan, Qiang Yuan, Qiang Yuan, Jun Zhang, Jun Zhang, Jun Zhang, Jun Zhang, Jun Zhang, Qifang Chen, Qifang Chen, Qifang Chen, Qifang Chen, Qifang Chen, Gang Wu, Gang Wu, Gang Wu, Gang Wu, Gang Wu, Jin Hu, Jin Hu, Jin Hu, Jin Hu, Jin Hu   +39 more
doaj   +1 more source