Results 91 to 100 of about 4,722 (203)

Identification of a New Family of Enzymes with Potential \u3cem\u3eO\u3c/em\u3e-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria [PDF]

, 2005
Background: The metabolism of the rigid bacterial cell wall heteropolymer peptidoglycan is a dynamic process requiring continuous biosynthesis and maintenance involving the coordination of both lytic and synthetic enzymes.
Clarke, Anthony J., Pfeffer, John M., Weadge, Joel T.   +2 more
core   +1 more source

Altered competitive fitness, antimicrobial susceptibility, and cellular morphology in a triclosan-induced small-colony variant of staphylococcus aureus [PDF]

, 2015
Staphylococcus aureus can produce small-colony variants (SCVs) that express various phenotypes. While their significance is unclear, SCV propagation may be influenced by relative fitness, antimicrobial susceptibility, and the underlying mechanism.
Bazaid, Abdulrahman, Forbes, Sarah, Latimer, Joe, Mcbain, Andrew, Mcbain, Andrew J   +4 more
core   +1 more source

Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli [PDF]

, 2023
Moneca Kaul, Suraj Kumar Meher, Manjula Reddy   +2 more
openalex   +1 more source

Phage and Endolysin Therapy Against Antibiotics Resistant Bacteria: From Bench to Bedside

MedComm, Volume 6, Issue 7, July 2025.
Synergistic effects of combining bacteriophages and antibiotics in antimicrobial therapy. The diagram illustrates key advantages of phage‐antibiotic synergy, including increased treatment effectiveness, reduced minimum inhibitory concentration (MIC) for drug‐resistant strains, enhanced biofilm eradication, and inhibition of resistant bacteria ...
Majid Taati Moghadam, Samane Mohebi, Raheleh Sheikhi, Meysam Hasannejad‐Bibalan, Shahla Shahbazi, Shadman Nemati   +5 more
wiley   +1 more source

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger, Gabriel Torrens, Felipe Cava, Thomas G. Bernhardt, Coralie Fumeaux   +4 more
doaj   +1 more source

Mycobacteriophage endolysins: diverse and modular enzymes with multiple catalytic activities. [PDF]

PLoS ONE, 2012
The mycobacterial cell wall presents significant challenges to mycobacteriophages--viruses that infect mycobacterial hosts--because of its unusual structure containing a mycolic acid-rich mycobacterial outer membrane attached to an arabinogalactan layer ...
Kimberly M Payne, Graham F Hatfull
doaj   +1 more source

Promiscuous, non-catalytic, tandem carbohydrate-binding modules modulate the cell-wall structure and development of transgenic tobacco (Nicotiana tabacum) plants [PDF]

, 2007
We have compared heterologous expression of two types of carbohydrate binding module (CBM) in tobacco cell walls. These are the promiscuous CBM29 modules (a tandem CBM29-1-2 and its single derivative CBM29-2), derived from a non-catalytic protein1 ...
Blake, AW, Gilbert, H, Jacobsen, E, Knox, JP, Obembe, OO, Timmers, J, Vincken, JP, Visser, RG   +7 more
core   +4 more sources

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Neisseria gonorrhoeae Uses Two Lytic Transglycosylases To Produce Cytotoxic Peptidoglycan Monomers [PDF]

Journal of Bacteriology, 2008
ABSTRACT Peptidoglycan fragments released by Neisseria gonorrhoeae contribute to the inflammation and ciliated cell death associated with gonorrhea and pelvic inflammatory disease. However, little is known about the production and release of these fragments during bacterial growth.
Karen A, Cloud-Hansen, Kathleen T, Hackett, Daniel L, Garcia, Joseph P, Dillard   +3 more
openaire   +2 more sources

Adaptive Evolution of Escherichia coli to an α-Peptide/β-Peptoid Peptidomimetic Induces Stable Resistance. [PDF]

, 2013
Antimicrobial peptides (AMPs) and synthetic analogues thereof target conserved structures of bacterial cell envelopes and hence, development of resistance has been considered an unlikely event.
A Bateman, A Peschel, A Skiada, Anne Holch, AT Yeung, B Deslouches, BA Napier, C Foged, C Muller, C Odio, CA Olsen, CA Olsen, CH Porsby, CL Quave, DA Steinberg, DJ Farrell, DM Bowdish, EL Hazen, F Zaknoon, G Bell, G Bonke, G Wang, GG Perron, H Zinsser, Henrik Franzyk, HH Lee, HS Girgis, HW Boucher, HY Cheng, IS Radzishevsky, JM Froelich, JS Gunn, K Nummila, KL Brown, L Fernandez, L Hein-Kristensen, Line Hein-Kristensen, Lone Gram, M Adam, M Zasloff, MA Fischbach, Mark Alexander Webber, ME Falagas, N Srinivas, N Weatherspoon-Griffin, NP Chongsiriwatana, P Dalgaard, PH Mygind, RE Hancock, RE Hancock, RL Gallo, SC Park, SO Rahaman, SS Lim, T Bjarnsholt, UW Sallum, WL Zhu, XN Jing, Y Chen, Z Xu, Z Zhou   +60 more
core   +7 more sources