Bacterial lytic transglycosylases: Biochemical characterization and rational design of inhibitors
Lytic transglycosylases cleave the [beta]-(1[right arrow]4) glycosidic bond in the bacterial cell wall heteropolymer, peptidoglycan, between the ' N'-acetylmuramic acid (MurNAc) and 'N'-acetylglucosamine (GlcNAc) residues with the concomitant formation of a 1,6 anhydromuramoyl residue.
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β-Lactam Resistance in Azospirillum baldaniorum Sp245 Is Mediated by Lytic Transglycosylase and β-Lactamase and Regulated by a Cascade of RpoE7→RpoH3 Sigma Factors. [PDF]
Pandey P +5 more
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This thesis is an investigation of the activity of the hypothetical protein product of the open reading frame from 'Escherichia coli' identified as 'yfhD'. We demonstrated that YfhD functions as a lytic transglycosylase (LT) and renamed it membrane-bound lytic transglycosylase F (MltF).
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Modulation of the Enzymatic Activity of the Flagellar Lytic Transglycosylase SltF by Rod Components and the Scaffolding Protein FlgJ in Rhodobacter sphaeroides. [PDF]
García-Ramos M +4 more
europepmc +1 more source
Antimicrobial resistance is a significant global public health issue, and the dissemination of antibiotic resistance in Gram-positive bacterial pathogens has significantly increased morbidity, mortality rates, and healthcare costs.
Mina Golban +3 more
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An inhibitor/anti-inhibitor system controls the activity of lytic transglycosylase MltF in Pseudomonas aeruginosa [PDF]
Michelle Wang +2 more
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Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand [PDF]
E.J. van Asselt +5 more
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Identification of type VI secretion system effector-immunity pairs using structural bioinformatics
The type VI secretion system (T6SS) is an important mediator of microbe–microbe and microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors (T6Es), which are usually proteins with toxic activity, into neighboring cells ...
Alexander M Geller +4 more
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Les liaisons dangereuses: Immunological synapse formation in animals and plants [PDF]
Kwon, C. +2 more
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