Results 81 to 90 of about 4,722 (203)

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen [PDF]

, 2019
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis, remains one of the leading causes of mortality across the world. There is an urgent requirement to build a robust arsenal of effective antimicrobials, targeting novel ...
Bhakta, S, Healy, J, Keep, NH, Maitra, A, Martin, LT, Munshi, TK, Vollmer, W   +6 more
core   +2 more sources

The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode [PDF]

, 2005
Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even
, Akman, Alla Lapidus, Altschul, Altschul, Amiri, Anamitra Bhattacharyya, Andersson, Andersson, Aras, Aultman, Balakirev, Bandi, Bandi, Bandi, Bandi, Bandi, Barker, Barton Slatko, Bazzocchi, Bazzocchi, Beard, Besemer, Booth, Bordenstein, Bordenstein, Bosshardt, Bourtzis, Bourtzis, Brattig, Brattig, Brattig, Brayton, Brenot, Campbell, Casiraghi, Casiraghi, Casiraghi, Caturegli, Chirgwin, Chirgwin, Chirgwin, Cloud, Collins, Cross, Curtis, Daubin, den Blaauwen, Dobson, Donald Comb, Dumler, Durvasula, Egyed, Elodie Ghedin, Eugene Goltsman, Eugene Koonin, Ewing, Ewing, Fischer, Flieger, Foster, Francis, Freedman, Genchi, Genchi, Ghedin, Gil, Gordon, Gouin, Grant, Grigoriev, Haarbrink, Haarbrink, Hall, Hise, Hise, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoerauf, Hoffman, Hougard, Howell, Ibrahim Kamal, Janos Posfai, Jeng, Jennifer Ware, Jeremy Foster, Jessica Ingram, Jeyaprakash, Jolodar, Kanehisa, Keiser, King, Kira Makarova, Kiryl Tsukerman, Klasson, Kozek, Kozek, Kramer, Kuhn, Kumar, Kurtz, Lamb, Langworthy, Larson, Laurie Moran, Laven, Letunic, Li, Lin, Lin, Lo, Locht, Lowe, MacDonald, Mackenzie, Makarova, Marina Omelchenko, McGuffin, McLaren, Mehul Ganatra, Mikhail Mazur, Mira, Molyneux, Moran, Moran, Moran, Moran, Nancy A. Moran, Narita, Natalia Ivanova, Nielsen, Nikos Kyrpides, O'Neill, Olga Ostrovskaya, Ottesen, Ottesen, Ottesen, Overbeek, Pearlman, Plenge-Bonig, Powell, Powell, Prichard, Prichard, Punkosdy, Rajan, Rao, Rao, Rao, Reader, Richards, Roux, Rubtsov, Saint Andre, Sanjay Kumar, Selkirk, Sexton, Shigenobu, Shiliang Wang, Shukla-Dave, Sinkins, Sinkins, Sinkins, Sironi, Slatko, Slesarev, Smith, Suetsugu, Sun, Tamas, Tamas, Tamas Vincze, Tatusov, Taylor, Taylor, Taylor, Taylor, Taylor, Taylor, Taylor, Townson, van Ham, Vandekerckhove, Victor Joukov, Vinayak Kapatral, Vincent, Warbrick, Ware, Warren, Wernegreen, Wernegreen, Werren, Werren, Werren, Werren, Williams, Wolf, Wu, Zabalou   +204 more
core   +3 more sources

Secreted Glycoside Hydrolase BcGH61 From Botrytis cinerea Induces Cell Death by the Apoplastic Location and Triggers Intracellular Immune Perception

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
We present a dual‐action virulence paradigm for BcGH61: Extracellularly, BcGH61 glycoside hydrolase degrades cell walls, releasing DAMPs that activate PRR‐mediated cell death. Intracellularly, it targets chloroplasts via NbHrBP1 interaction at plastoglobule‐thylakoid interfaces, paradoxically activating defence signalling while priming immunity‐related
Wenjun Zhu, Ziyao Wang, Can Zheng, Min Fang, Binbin Huang, Xiaofei Nie, Yong Liang, Zhaoxia Li, Kai Bi   +8 more
wiley   +1 more source

Substrate-Assisted Catalysis Unifies Two Families of Chitinolytic Enzymes [PDF]

, 1997
Hen egg-white lysozyme has long been the paradigm for enzymatic glycosyl hydrolysis with retention of configuration, with a protonated carboxylic acid and a deprotonated carboxylate participating in general acid-base catalysis.
Blake C. C. F., C−, Davies G. J., Ford L. O., Henrissat B., Iseli B., Johnson L. N., Jones T. A., Kirby A., Knapp S., Kobayashi S., Koshland D. E., Perrakis A., Phillips D. C., Piszkiewicz D., Rao V. H., Rozeboom H. J., Sinnot M. L., Strynadka N. C. J., Sulzenbacher G., Terwisscha van Scheltinga A. C., Terwisscha van Scheltinga A. C., Terwisscha van Scheltinga A. C., Tews I., Thunnissen A. M. W. H., Tronrud D. E., van Roey P., Vårum K. M., Weaver L. H.   +28 more
core   +3 more sources

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy [PDF]

, 2018
Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents, especially against multi-drug resistant pathogens. Herein we present a review about the biological features of virion-associated lysins and endolysins, phage-derived ...
Azeredo, Joana, Oliveira, Hugo, São-José, Carlos   +2 more
core   +2 more sources

Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
We isolated phage UE‐M6 from wastewater and subsequently cloned, expressed, and purified its encoded endolysin (UE‐lysin) and holin (UE‐holin). Our results demonstrate that the combined application of UE‐lysin and UE‐holin exhibits significantly greater antibacterial activity than either protein alone, indicating a synergistic interaction between the ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
wiley   +1 more source

The interplay between Acinetobacter baumannii ZigA and SltB promotes zinc homeostasis and cell envelope integrity

Infection and Immunity
Acinetobacter baumannii is an opportunistic human pathogen that acquires nutrient metals from the vertebrate host amid infection. During zinc (Zn) scarcity, A. baumannii upregulates the expression of the predicted Zn metallochaperone, zigA.
Jeanette M. Critchlow, Juan P. Barraza, Matthew J. Munneke, Evan Krystofiak, Erin R. Green, Eric P. Skaar   +5 more
doaj   +1 more source

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]

, 2012
UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles, Cokus, Shawn, Fitz-Gibbon, Sorel, Hatfull, Graham F, Hayes, Clarmyra, Inkeles, Megan, Jacobs-Sera, Deborah, Kim, Jenny, Loncaric, Anya, Marinelli, Laura J, Miller, Jeff F, Modlin, Robert L, Pellegrini, Matteo, Russell, Daniel A   +13 more
core   +2 more sources

Environmental Antimicrobial Resistance: Key Drivers, Hotspots, Innovative Strategies, and Challenges in the Fight Against Superbugs

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem, Mulat Dagnew, Mucheye Gizachew, Baye Gelaw, Feleke Moges   +4 more
wiley   +1 more source