Results 21 to 30 of about 15,108 (126)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

IFN-γ +874 T/A Is Associated with High Levels of Sera CPK in Patients with Inflammatory Myopathies

Current Issues in Molecular Biology
Aim of the study: Idiopathic inflammatory myopathies (IIM) are autoimmune diseases with a low prevalence and incidence worldwide. The levels of IFN-γ production by T-lymphocytes are related to disease activity.
Mónica Vázquez-Del Mercado, Beatriz Teresita Martín-Márquez, Erika Aurora Martínez-García, Marcelo Heron Petri   +3 more
doaj   +1 more source

Doença de Lafora: diagnóstico pela biopsia de músculo esquelético (relato de caso) Lafora's disease: diagnosis by muscle biopsy (case report)

Arquivos de Neuro-Psiquiatria, 2000
Uma paciente de 16 anos apresentava epilepsia mioclônica causada pela doença de Lafora. A biopsia muscular mostrou padrão vacuolar nas fibras musculares com as reações nicotinamida adenina tetrazolium redutase desidrogenase, hematoxilina-eosina e PAS.
ALZIRA ALVES DE SIQUEIRA CARVALHO, VIVIANA PALOU, MARIA SHEILA GUIMARÃES ROCHA, SONIA MARIA DOZZI BRUCKI, MEIRE ARGENTONI   +4 more
doaj   +1 more source

Diagnostic Yield of Post‐Mortem Fetal Micro‐CT for Abdominal and Pelvic Anomalies

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective(s) This study aims to document the abdominal and pelvic anomalies that can be demonstrated using post mortem Micro‐CT, independent of whether the anomaly contributed to the main diagnosis or cause of death. Methods We retrospectively analyzed 1200 whole body post‐mortem fetal Micro‐CT scans in an unselected, consecutive cohort ...
Ian C. Simcock, Audrey Lamouroux, Susan C. Shelmerdine, J. Ciaran Hutchinson, Neil J. Sebire, Owen J. Arthurs   +5 more
wiley   +1 more source

Dengue: muscle biopsy findings in 15 patients

Arquivos de Neuro-Psiquiatria, 1993
Dengue is known to produce a syndrome involving muscles, tendons and joints. The hallmark of this syndrome is severe myalgia but includes fever, cutaneous rash, and headache.
S.M.F. Malheiros, A.S.B. Oliveira, B. Schmidt, J.G. Camargo Lima, A.A. Gabbai   +4 more
doaj   +1 more source

Diagnostic Yield of Post‐Mortem Fetal Micro‐CT for Central Nervous System Abnormalities

Prenatal Diagnosis, EarlyView.
ABSTRACT Objectives This study demonstrates the central nervous system (CNS) abnormalities detected using fetal post‐mortem micro‐focus computed tomography (Micro‐CT), independent of whether the abnormality contributed to the main diagnosis or cause of death.
Ian C. Simcock, Audrey Lamouroux, Susan C. Shelmerdine, J. Ciaran Hutchinson, Neil J. Sebire, Owen J. Arthurs   +5 more
wiley   +1 more source

Desempenho e morfologia hepática de juvenis de tilápia-do-nilo alimentados com dietas suplementadas com metionina e colina Performance and hepatic morphology of Nile tilapia juveniles fed methionine and choline supplemented diets

Pesquisa Agropecuária Brasileira, 2010
O objetivo deste trabalho foi avaliar os efeitos da metionina e colina sobre o desempenho produtivo e a morfologia do fígado de tilápia-do-nilo. Durante 87 dias, 160 peixes da linhagem Supreme, com peso vivo médio inicial de 77±0,8 g, distribuídos ...
Thêmis Sakaguti Graciano, Maria Raquel Marçal Natali, Luiz Vítor Oliveira Vidal, Mariana Michelato, José Sérgio Righetti, Wilson Massamitu Furuya   +5 more
doaj   +1 more source

Analysis of the nursing diagnosis of [ineffective breathing pattern (00032)] in patients hospitalized with COVID‐19: A cross‐sectional study

International Journal of Nursing Knowledge, EarlyView.
Abstract Purpose To analyze the prevalence, accuracy of clinical indicators and related factors of the nursing diagnosis of ineffective breathing pattern (00032) in patients hospitalized due to COVID‐19. Methods This is a cross‐sectional study conducted in a public hospital, involving 250 adult hospitalizations between 2020 and 2021.
Caio Rodrigo Menezes dos Santos, Thiago de Jesus Santos, Andreia Centenaro Vaez, Damião da Conceição Araújo   +3 more
wiley   +1 more source

Treino de músculos inspiratórios em doentes com DPOC

Revista Portuguesa de Pneumologia, 2008
Resumo: Objectivo: Pretendemos investigar os efeitos de um protocolo específico de treino dos músculos inspiratórios (TMI) no comportamento da dispneia, da função pulmonar, da força dos músculos respiratórios, da tolerância ao exercício e da qualidade de vida, num grupo de doentes com doença pulmonar obstrutiva crónica (DPOC).Amostra ...
Susana Garcia, Margarida Rocha, Paula Pinto, António M.F. Lopes, Cristina Bárbara   +4 more
openaire   +1 more source

Delayed Loop Ileostomy Reversal Increases the Risk of Colitis and Clostridium difficile Infection

ANZ Journal of Surgery, EarlyView.
Delayed loop ileostomy reversal is associated with increased post‐operative complications specifically colitis and Clostridium difficile colitis. The COVID‐19 pandemic caused a significant delay in ileostomy reversal timing. ABSTRACT Background Temporary loop ileostomy formation is a routine procedure performed to protect distal colorectal anastomosis.
Yan S. Tan, S. Fujino, Marcus E. H. Chan, Johann W. Z. Leh, Asiri M. K. Arachchi, V. Narasimhan, Thomas S. Suhardja, Hanumant S. Chouhan, Pathirajage C. K. Saranasuriya, James T. Lim, Thang C. Nguyen, William M. K. Teoh, Yeng K. Tay   +12 more
wiley   +1 more source