Results 31 to 40 of about 52,089 (143)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Desempenho e morfologia hepática de juvenis de tilápia-do-nilo alimentados com dietas suplementadas com metionina e colina Performance and hepatic morphology of Nile tilapia juveniles fed methionine and choline supplemented diets

Pesquisa Agropecuária Brasileira, 2010
O objetivo deste trabalho foi avaliar os efeitos da metionina e colina sobre o desempenho produtivo e a morfologia do fígado de tilápia-do-nilo. Durante 87 dias, 160 peixes da linhagem Supreme, com peso vivo médio inicial de 77±0,8 g, distribuídos ...
Thêmis Sakaguti Graciano, Maria Raquel Marçal Natali, Luiz Vítor Oliveira Vidal, Mariana Michelato, José Sérgio Righetti, Wilson Massamitu Furuya   +5 more
doaj   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Treino de músculos inspiratórios em doentes com DPOC

Revista Portuguesa de Pneumologia, 2008
Resumo: Objectivo: Pretendemos investigar os efeitos de um protocolo específico de treino dos músculos inspiratórios (TMI) no comportamento da dispneia, da função pulmonar, da força dos músculos respiratórios, da tolerância ao exercício e da qualidade de vida, num grupo de doentes com doença pulmonar obstrutiva crónica (DPOC).Amostra ...
Susana Garcia, Margarida Rocha, Paula Pinto, António M.F. Lopes, Cristina Bárbara   +4 more
openaire   +1 more source

Proportion, Five‐Year Survival Rate of Laryngeal Cancer and Its Associated Factors Among Head and Neck Cancer Patients in Tanzania

Eye &ENT Research, EarlyView.
ABSTRACT Background Laryngeal cancer carries a significant global burden, with substantial morbidity and mortality, and is increasing globally, with 95%–98% being squamous cell carcinoma. Males are more affected than females, with peak cases occurring between 60 and 80 years of age.
Amenye Adili, Furaha Serventi, Baraka M. Musimu, Mica Magembe, Orest Tarimo, Geofrey Ikelesho, Salum Kalonge, Leonard Kiboko, Queen Godfrey Tarimo, Desderius C. Chussi   +9 more
wiley   +1 more source

Avaliação da função dos músculos respiratórios em doentes com falência ventricular esquerda

Revista Portuguesa de Pneumologia, 2001
RESUMO: A diminuição da força dos músculos respiratórios, determinada pela medição das pressões máximas respiratórias a nível da boca, tem sido evocada como um dos mecanismos geradores de dispneia em doentes com insuficiência cardíaca esquerda (ICE).
Miguel Mota Carmo, Cristina Bárbara, Sara Ferreira, Jaime Branco, Teresa Ferreira, António Rendas   +5 more
openaire   +1 more source

Serum osteocalcin is associated with scintigraphic abnormalities in lame and clinically sound racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Musculoskeletal injury is a major welfare and economic challenge in racehorses, with stress‐related bone injury contributing to training interruption and catastrophic failure. Advanced imaging modalities can detect early skeletal pathology but remain limited in routine screening environments.
Peter Tually, Dominique Blache, Jack Meadows, Shiphrah Tagore, Paul O'Callaghan, Matilda Hathway, Ian Fulton, Geoffrey Currie   +7 more
wiley   +1 more source

YKL-40 serum levels are predicted by inflammatory state, age and diagnosis of idiopathic inflammatory myopathies

Scientific Reports, 2023
YKL-40 increase according to the aging process, and its functions have been associated with tissue remodeling and systemic inflammation. In Rheumatoid Arthritis (RA) it has been proposed as a possible biomarker of activity and severity, however; in the ...
Mónica Vázquez-Del Mercado, Felipe Pérez-Vázquez, Ana L. Márquez-Aguirre, Erika-Aurora Martínez-García, Efrain Chavarria-Avila, Carlos G. Ramos-Becerra, Andrea Aguilar-Vázquez, Marisol Godínez-Rubí, Beatriz-Teresita Martín-Márquez, Livier Gómez-Limón, Guillermo Márquez-De-La-Paz, Edy-David Rubio-Arellano, Oscar Pizano-Martinez   +12 more
doaj   +1 more source

Diagnostic Yield of Post‐Mortem Fetal Micro‐CT for Abdominal and Pelvic Anomalies

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective(s) This study aims to document the abdominal and pelvic anomalies that can be demonstrated using post mortem Micro‐CT, independent of whether the anomaly contributed to the main diagnosis or cause of death. Methods We retrospectively analyzed 1200 whole body post‐mortem fetal Micro‐CT scans in an unselected, consecutive cohort ...
Ian C. Simcock, Audrey Lamouroux, Susan C. Shelmerdine, J. Ciaran Hutchinson, Neil J. Sebire, Owen J. Arthurs   +5 more
wiley   +1 more source

Fadiga nos portadores de lúpus eritematoso sistemático sob intervenção fisioterapêutica

O Mundo da Saúde, 2006
O lúpus eritematoso sistêmico (LES) é uma doença inflamatória com manifestações polimórficas que podem comprometer diversos órgãos e sistemas, como pele, músculos, articulações, rins, coração, vasos, sangue, pulmões e sistema nervoso.
Jusiana Mara Chimelo Peres, Paula de Freitas Bambini Tedde, Neuseli Marino Lamari   +2 more
doaj