Results 211 to 220 of about 26,727 (247)

Antibodies to m‐type phospholipase A2 receptor in children with idiopathic membranous nephropathy

Nephrology, 2015
AbstractIdiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m‐type phospholipase A2 receptor (PLA2R) are seen in two‐thirds of adult IMN cases.
Vinod, Kumar, Raja, Ramachandran, Ashwani, Kumar, Ritambhra, Nada, Deepti, Suri, Anju, Gupta, Harbir Singh, Kohli, Krishan Lal, Gupta, Vivekanand, Jha   +8 more
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M-type phospholipase A2 receptor (PLA2R) glomerular staining in pediatric idiopathic membranous nephropathy

Pediatric Nephrology, 2016
Identifying M-type phospholipase A2 receptor (PLA2R) is a landmark breakthrough for understanding adult idiopathic membranous nephropathy (iMN). However, potential roles for PLA2R in pediatric iMN have not been well investigated.A total of 34 pediatric iMN patients who underwent kidney biopsy between 1972 and 2015 were enrolled in this study. The study
Shoichiro, Kanda, Shigeru, Horita, Takeshi, Yanagihara, Akira, Shimizu, Motoshi, Hattori   +4 more
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Clinicopathological characteristics of M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy in Japanese

Clinical and Experimental Nephrology, 2014
Recent studies have suggested that assessments of serum antibodies against M-type phospholipase A2 receptor (PLA2R) and the glomerular expression of PLA2R antigen in biopsy specimens are useful for the diagnosis of primary membranous nephropathy (MN).
Norifumi, Hayashi, Shin'ichi, Akiyama, Hiroshi, Okuyama, Yuki, Matsui, Hiroki, Adachi, Hideki, Yamaya, Shoichi, Maruyama, Enyu, Imai, Seiichi, Matsuo, Hitoshi, Yokoyama   +9 more
openaire   +2 more sources

Antibodies to M-type phospholipase A2 receptor (PLA ₂ R) in membranous lupus nephritis

Lupus, 2019
Background Antibodies to M-type phospholipase A2 receptor (a-PLA 2 R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear.
E Garcia-Vives, C Solé, T Moliné, A M Alvarez-Rios, M Vidal, I Agraz, J Ordi-Ros, J Cortés-Hernández   +7 more
openaire   +2 more sources

Multifunctional activity of the extracellular domain of the M-Type (180 kDa) membrane receptor for secretory phospholipases A2

Biochemistry, 1995
M-type (180 kDa) receptors for secretory phospholipases A2 (sPLA2s) are thought to mediate some of the physiological effects of group I sPLA2, including smooth muscle contraction and cell proliferation. The M-type sPLA2 receptor is a large glycoprotein composed of several distinct extracellular domains which belongs to the C-type lectin superfamily ...
P, Ancian, G, Lambeau, M, Lazdunski
openaire   +2 more sources

M-Type Phospholipase A2 Receptor Autoantibody Measured by ELISA has Diagnostic Value in Patients with Idiopathic Membranous Nephropathy

Clinical Laboratory, 2023
This study investigated the diagnosis value of phospholipase A2 receptor autoantibodies (PLA2R-AB) for idiopathic membranous nephropathy (IMN).Patients with IMN, lupus nephritis, hepatitis B virus-associated nephropathy and IgA nephropathy and healthy participants were included. Receiver operating characteristics (ROC) curve was plotted for PLA2R-AB to
Jing, Li, Aerxin, Mulatibieke, Shuyuan, Liu, Yelixiati, Adelibieke, Chen, Dai, Suolinge, Chahan, Huayun, Chen   +6 more
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Abstract A159: Epigenetic silencing of the M-type phospholipase A2 receptor gene in leukemic cells.

Molecular Cancer Therapeutics, 2011
Abstract Background: The M-type phospholipase A2 receptor (PLA2R) plays a crucial role in a number of different signaling pathways and may act as tumor-suppressor. In the current study the expression and methylation of the PLA2R gene in the myeloid U937 cell line and blood leukocytes of patients with leukemia were analyzed.
Mario Menschikowski, Uwe Platzbecker, Albert Hagelgans, Margot Vogel, Christian Thiede, Claudia Schoenefeldt, Graeme Eisenhofer, Gabriele Siegert   +7 more
openaire   +1 more source

Antibodies against M-Type Phospholipase A2 Receptor May Predict Treatment Response and Outcome in Membranous Nephropathy

American Journal of Nephrology, 2018
<b><i>Background:</i></b> Anti-phospholipase A₂ receptor (PLA2R) antibodies are specific to the diagnosis of primary membranous nephropathy (pMN). The prevalence of positive antibodies varies among different cohorts.
Zhen, Qu, Mu-Fan, Zhang, Zhao, Cui, Jia, Wang, Miao, Wang, Yi-Miao, Zhang, Fang, Wang, Xin, Wang, Li-Qiang, Meng, Xu-Yang, Cheng, Gang, Liu, Ming-Hui, Zhao   +11 more
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Secreted Phospholipase A₂Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor

Biochemistry, 2006
Mammalian secreted phospholipases A(2) (sPLA(2)s) constitute a family of structurally related enzymes that are likely to play numerous biological roles because of their phospholipid hydrolyzing activity and binding to soluble and membrane-bound proteins, including the M-type receptor.
Eric, Boilard, Morgane, Rouault, Fanny, Surrel, Catherine, Le Calvez, Sofiane, Bezzine, Alan, Singer, Michael H, Gelb, Gérard, Lambeau   +7 more
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High-Molecular-Mass Receptors for Ammodytoxin in Pig Are Tissue-Specific Isoforms of M-Type Phospholipase A2 Receptor

Biochemical and Biophysical Research Communications, 2001
Studying the molecular basis of presynaptic neurotoxicity of ammodytoxin C, a secretory phospholipase A(2) from the venom of Vipera a. ammodytes snake, we demonstrated the existence of two high-molecular-mass ammodytoxin C-binding proteins in porcine tissues, one in cerebral cortex and the other in liver. These proteins differ considerably in stability
N, Vardjan, N E, Sherman, J, Pungercar, J W, Fox, F, Gubensek, I, Krizaj   +5 more
openaire   +2 more sources