Results 111 to 120 of about 378,588 (317)

Missed opportunities for tuberculosis diagnosis. [PDF]

, 2011
BACKGROUND: In high tuberculosis (TB) burden, resource-poor countries, sputum smear microscopy remains the mainstay of diagnosis. The low sensitivity of this test means that patients with smear-negative but culture-positive TB pass undetected through the
Trejos, N, Bailey, SL, Roper, MH, Moore, DAJ, Huayta, M, López Alarcón, V   +5 more
core  

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean

, 2008
Background: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia.
Eshed Vered, David E Minnikin, Besra, Gurdyal; id_orcid, Bargal, GK, Mark Spigelman, Bar-Gal Gila Kahila, Donoghue, HD, Hershkovitz Israel, Gernaey, AM, Bar-Gal, GK, Spigelman, M, Vered Eshed, Lemma, E, Galili Ehud, Gernaey Angela M., Minnikin David E., Spigelman Mark, Lemma Eshetu, Eshed, V, Eshetu Lemma, Charles L Greenblatt, Oona Y-C Lee, Lee Oona Y-C., Galili, E, Gurdyal S Besra, Donoghue Helen D., Greenblatt, CL, Besra, GS, Angela M Gernaey, Lee, Oona, Hershkovitz, I, Ehud Galili, Minnikin, DE, Besra Gurdyal S., Minnikin, David, Lee, OYC, Gila Kahila Bar-Gal, Helen D Donoghue, Israel Hershkovitz, Greenblatt Charles L.   +39 more
core   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

The anti-tubercular activity of Melia azedarach L. and Lobelia chinensis Lour. and their potential as effective anti-Mycobacterium tuberculosis candidate agents

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To evaluate the anti-mycobacterial activity of Melia azedarach L. (M. azedarach) and Lobelia chinensis Lour. (L. chinensis) extracts against the growth of Mycobacterium tuberculosis (M. tuberculosis). Methods: The anti-M. tuberculosis activity
Won Hyung Choi, In Ah Lee
doaj   +1 more source

Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M. bovis BCG Copenhagen.

, 2003
A comprehensive analysis of culture supernatant (CSN) proteins of Mycobacterium tuberculosis H37Rv was accomplished by combination of two-dimensional electrophoresis (2-DE), mass spectrometry, and N-terminal sequencing by Edman degradation.
Hagens, Kristine, Jens Mattow, Schmidt, F., Kaufmann, Stefan H. E., Jungblut, Peter R., Jungblut, Peter R, Hagens, K., Mueller, E.C., Frank Schmidt, Kaufmann, Stefan HE, Ulrich E. Schaible, Frank Siejak, Schaible, Ulrich E, Müller, Eva-Christina, Eva‐Christina Müller, Schaible, Ulrich E., Brestrich, Gordon, Siejak, Frank, Kristine Hagens, Mattow, J., Siejak, R., Peter R. Jungblut, Schmidt, Frank, Gisela Haeselbarth, Stefan H. E. Kaufmann, Haeselbarth, G., Haeselbarth, Gisela, Mattow, Jens, Gordon Brestrich, Jungblut, P.R., Kaufmanni, S.H.E., Schaible, U.E., Brestrich, G.   +32 more
core   +1 more source

The granuloma in tuberculosis: dynamics of a host-pathogen collusion. [PDF]

, 2012
A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the bacteria may disseminate.
Ulrich E. Schaible, Stefan Ehlers, Schaible, Ulrich E, Stefan eEhlers, Ulrich E Schaible, Ehlers, Stefan   +5 more
core   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source