Results 91 to 100 of about 24,558,315 (312)

PRECLINICAL STUDIES OF THE SPECIFIC ACTIVITY OF THE NEW ANTITUBERCULOSIS DRUG THIOZONIDE

open access: yesТуберкулез и болезни лёгких, 2014
In vitro and in vivo preclinical studies of the antituberculosis activity of thiozonide designed at the ZAO “Farn-Sintez” (Moscow) were conducted at the Central Research of Tuberculosis, Russian Academy of Medical Sciences.
I. V. Bocharova   +5 more
doaj   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

open access: yesAdvanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao   +13 more
wiley   +1 more source

Complications after BCG vaccination in a big city

open access: yesТуберкулез и болезни лёгких, 2016
Complications after specific prevention of tuberculosis for the last 10 years have been analyzed using the example of a big city. The frequency of severe complications (BCG-ostitis) made 0.004% and the frequency of minor complications (lymphadenitis ...
T. A. Sevostyanova   +2 more
doaj   +1 more source

The granuloma in tuberculosis: dynamics of a host-pathogen collusion. [PDF]

open access: yes, 2012
A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the bacteria may disseminate.
Ulrich E. Schaible   +5 more
core   +1 more source

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

open access: yesAdvanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang   +12 more
wiley   +1 more source

Isoniazid-resistant TB and associated factors in Ethiopia

open access: yesPublic Health Action
BACKGROUND: Isoniazid-resistant, rifampicin-susceptible Mycobacterium tuberculosis (Hr-TB) is the most common form of drug-resistant TB (DR-TB). We investigated the prevalence of and risk factors for Hr-TB in Ethiopia.
S. Moga   +8 more
doaj   +1 more source

Identification of Cytomegalo Virus Infection Among Mycobacterium Tuberculosis in Baghdad City. Correlation between TB and CMV infection [PDF]

open access: yesModern Medicine
Objectives: Human cytomegalovirus (HCMV) infection and immunological activation are risk factors for tuberculosis disease, according to recent research.
Ali AL-ATTWANI, Oral DÜZDEMIR
doaj   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu   +9 more
wiley   +1 more source

XPERT MTB/RIF TEST FOR THE DIAGNOSIS OF TUBERCULOSIS AND RIFAMPICIN RESISTANCE: RESULTS OF ITS INTRODUCTION IN THE KYRGYZ REPUBLIC

open access: yesТуберкулез и болезни лёгких, 2014
The Xpert MTB/RIF analysis was used to test 3,829 autopsy specimens. The detection rate of rifampicin-resistant tuberculosis averaged 13%. The fact that the detection rate of patients with multidrug-resistant tuberculosis was 5% among the new cases with ...
A. D. Adambekova   +2 more
doaj  

Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis: a systematic review. [PDF]

open access: yes, 2002
Strains of the Beijing/W genotype family of Mycobacterium tuberculosis have caused large outbreaks of tuberculosis, sometimes involving multidrug resistance. This genetically highly conserved family of M.
Judith R. Glynn   +10 more
core   +1 more source

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