Results 81 to 90 of about 378,588 (317)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Scientometric analysis of Mycobacterium tuberculosis revaccination: Dynamics, impact and analysis of collaborative networks

Lung India
Background: Mycobacterium tuberculosis (M. tuberculosis) is an infectious disease that remains a significant global health problem. Despite efforts to reduce the disease, the disease remains prevalent in many parts of the world.
Luis Roberto Checa Vieira, Aylén Solange Vásquez Dávila, Frank Mayta-Tovalino   +2 more
doaj   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

GENETIC STRUCTURE AND DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS POPULATION IN THE CIVIL SECTOR OF THE KYRGYZ REPUBLIC

Туберкулез и болезни лёгких, 2014
The genetic structure of drug-resistant and drug-susceptible Mycobacterium tuberculosis (MBT) circulating in the civil sector of the Kyrgyz Republic was analyzed.
Zh. T. Isakova, I. V. Mokrousov, N. Rastogi, A. A. Aldashev   +3 more
doaj  

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Definition desired mode ultraviolet radiation, which prevent Mycobacterium tuberculosis survival and conversion to L-forms

Annals of Mechnikov's Institute, 2020
Bactericidal effect of ultraviolet (UV) rays was first described over 100 years ago. UV was used in hospitals from 1930 and in 1936 was first used to sterilize the air in the operating room. The maximum bactericidal effect occurs in the region 254-257 nm
T Moiseenko, A Volyanski, A Kovaleva
doaj  

The timing of death in patients with tuberculosis who die during anti-tuberculosis treatment in Andhra Pradesh, South India

, 2011
Background: India has 2.0 million estimated tuberculosis (TB) cases per annum with an estimated 280,000 TBrelated deaths per year. Understanding when in the course of TB treatment patients die is important for determining the type of intervention to be ...
Tetali, S, Harries Anthony D, Rao Srinivas, Jonnalagada, Subbanna, Kannuri, Nanda K, Peri, Sundaresh, Kannuri, N K, Srinath Satyanarayana, Peri, S, Peri Sundaresh, Harries, Anthony D, Anchala, Raghupathy, Zachariah Rony, Anchala Raghupathy, Ranganadha Rao, Jonnalagada, S, Rao Ranganadha, Rao, Ranganadha, Jonnalagada Subbanna, Nanda K Kannuri, Zachariah, Rony, Rao, Srinivas, Harries, A D, Rao, S, Shailaja Tetali, Rao, R, Satyanarayana Srinath, Tetali Shailaja, Anthony D Harries, Satyanarayana, Srinath, Zachariah, R, Tetali, Shailaja, Anchala, R, Kannuri Nanda K, Satyanarayana, S, Keshav Chander, G, G Keshav Chander, Keshav Chander G, Sundaresh Peri, Raghupathy Anchala, Subbanna Jonnalagada, Rony Zachariah, Srinivas Rao   +42 more
core   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source