Results 71 to 80 of about 24,558,315 (312)

THE SEARCH OF OPTIMAL COMBINATION OF ANTIGENS FOR SEROLOGICAL DIAGNOSTICS OF TUBERCULOSIS

Инфекция и иммунитет, 2014
. The four chimeric recombinant antigens CBD-CFP10, CBD-ESAT6, ESAT6-CFP10 and CBD-P38 contained aminoacid sequences of full-size proteins ESAT6, CFP10 and matured protein P38 of M.
E. V. Vasilyeva, V. N. Verbov, A. B. Beklemishev, A. L. Mamaev, A. O. Tsyrul’nikov, T. A. Stepanenko, V. B. Ivanovskii, S. V. Lapin, Areg A. Totolian   +8 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)

Acta Biomedica Scientifica, 2019
The global spread of tuberculosis remains one of actual problems of public health despite of introduction of public health safety programs. Early, rapid and accurate identification of M. tuberculosis and determination of drug susceptibility are essential
P. A. Khromova, V. V. Sinkov, E. D. Savilov   +2 more
doaj   +1 more source

An investigation of the transmission dynamics of M. tuberculosis. [PDF]

We develop an age-structured deterministic model (TBDYN3) of the transmission dynamics of M. tuberculosis in England and Wales since 1900. The model estimates the age-specific risks of developing' primary', 'endogenous' and 'exogenous' disease and ...
Vynnycky, Emilia
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

DRUG RESISTANCE OF STRAINS OF M. TUBERCULOSIS, ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS IN VLADIMIR REGION IN 2013

Туберкулез и болезни лёгких, 2015
The study presents the analysis of drug susceptibility of tuberculosis mycobacteria isolated from pulmonary tuberculosis patients by the moment of their registration in 2013 on the territory of Vladimir region. Totally 574 pulmonary tuberculosis patients
E. S. Dyuzhik, N. V. Kaunetis, T. G. Smirnova, E. E. Larionova, G. V. Volchenkov   +4 more
doaj  

Changes in Mycobacterium tuberculosis genotype families over 20 years in a population-based study in Northern Malawi. [PDF]

, 2010
BACKGROUND: Despite increasing interest in possible differences in virulence and transmissibility between different genotypes of M. tuberculosis, very little is known about how genotypes within a population change over decades, or about relationships to ...
Houben, Rein M, Judith R. Glynn, Fine, Paul E.M., McNerney, Ruth, Glynn, Judith R., Neil French, Glynn, Judith R, French, Neil, Crampin, Amelia C, Rein M Houben, Paul E M Fine, Mallard, Kim, Judith R Glynn, Amelia C Crampin, Amelia C. Crampin, Paul E. M. Fine, Fine, Paul EM, Munthali, Lumbani, Crampin, Amelia C., Saad Alghamdi, Ruth McNerney, Lumbani Munthali, Alghamdi, Saad, Ndlovu, Richard, Rein M. Houben, Kim Mallard, Richard Ndlovu, Houben, Rein M., Munthali Lumbani, French Neil, Glynn Judith R., Alghamdi Saad, Fine Paul E. M., Houben Rein M., McNerney Ruth, Crampin Amelia C., Ndlovu Richard, Mallard Kim   +37 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Second worldwide proficiency study on variable number of tandem repeats typing of Mycobacterium tuberculosis complex

, 2014
Global Network for the Molecular Surveillance of Tuberculosis 2010: A. Miranda (Tuberculosis Laboratory of the National Institute of Health, Porto, Portugal)BACKGROUND: The quality of variable number of tandem repeats (VNTR) typing of Mycobacterium ...
Global Network for the Molecular Surveillance of Tuberculosis 2010, Ködmön, C., de Beer, J.L., de Beer, J. L., van Soolingen, D., van Ingen, J., Supply, P., Network For Molecular Surveillance of Tuberculosis 2010 (collaborators), Global   +7 more
core   +1 more source