Results 51 to 60 of about 24,558,315 (312)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

British Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright, Irene Rizzini, Malibongwe Gwele, Lynn McNair, Cristina Laclette Porto, Marsha Orgill, E. Kay M. Tisdall, Malcolm Bush, Linda Biersteker   +8 more
wiley   +1 more source

Treatment results of patients with multiple and extensive drug resistance registered in 2012 in the Russian Federation and in the world

Туберкулез и болезни лёгких, 2016
The chemotherapy results have been analyzed in tuberculosis patients suffering from multiple drug resistance registered for treatment in the Russian Federation in 2011-2012 compared with the treatment outcomes of MDR patients registered for treatment in ...
S. A. Sterlikov, V. V. Testov, I. A. Vasilieva   +2 more
doaj  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Comparative proteome analysis of culture supernatant proteins from virulent Mycobacterium tuberculosis H37Rv and attenuated M. bovis BCG Copenhagen.

, 2003
A comprehensive analysis of culture supernatant (CSN) proteins of Mycobacterium tuberculosis H37Rv was accomplished by combination of two-dimensional electrophoresis (2-DE), mass spectrometry, and N-terminal sequencing by Edman degradation.
Hagens, Kristine, Jens Mattow, Schmidt, F., Jungblut, Peter R, Hagens, K., Mueller, E.C., Frank Schmidt, Kaufmann, Stefan HE, Ulrich E. Schaible, Frank Siejak, Schaible, Ulrich E, Müller, Eva-Christina, Eva‐Christina Müller, Brestrich, Gordon, Siejak, Frank, Kristine Hagens, Mattow, J., Siejak, R., Peter R. Jungblut, Schmidt, Frank, Gisela Haeselbarth, Stefan H. E. Kaufmann, Haeselbarth, G., Haeselbarth, Gisela, Mattow, Jens, Gordon Brestrich, Jungblut, P.R., Kaufmanni, S.H.E., Schaible, U.E., Brestrich, G.   +29 more
core   +1 more source

Genomic Diversity among Beijing and non-Beijing Mycobacterium tuberculosis Isolates from Myanmar [PDF]

, 2008
Background: The Beijing family of Mycobacterium tuberculosis is dominant in countries in East Asia. Genomic polymorphisms are a source of diversity within the M. tuberculosis genome and may account for the variation of virulence among M.
Hinds Jason, Grewal, HM, Butcher, PD, Stavrum Ruth, Stavrum, R, Bø, TH, Ruth Stavrum, Valvatne, H, Trond H Bø, Jonassen, I, Philip D Butcher, Valvatne Håvard, Bø Trond H., Hinds, J, Butcher Philip D., Jonassen Inge, Inge Jonassen, Jason Hinds, Håvard Valvatne, Harleen M S Grewal, Grewal Harleen M. S.   +20 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA

eLife, 2017
RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and CarD cooperatively stimulate formation of an intermediate (RP2) leading to RPo; formation of RP2 ...
Elizabeth A Hubin, Allison Fay, Catherine Xu, James M Bean, Ruth M Saecker, Michael S Glickman, Seth A Darst, Elizabeth A Campbell   +7 more
doaj   +1 more source

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. [PDF]

, 2007
The Mycobacterium tuberculosis TetR-type regulator Rv3574 has been implicated in pathogenesis as it is induced in vivo, and genome-wide essentiality studies show it is required for infection.
Withers, Mike, Moreland, NJ, Sidders, B, Ben Sidders, Catherine N. Soffair, Besra, Gurdyal; id_orcid, ten Bokum, A, Ten Bokum, A M C, Kendall, Sharon L, Soffair, CN, Sudagar Gurcha, Stoker, NG, Rosangela Frita, Gurdyal S. Besra, Besra, G S, Moreland, Nicole J, Moreland, N J, Kendall, SL, J. Shaun Lott, Sidders, Ben, Frita, R, Soffair, Catherine N, Neil G. Stoker, Frita, Rosangela, Soffair, C N, Mike Withers, Gurcha, S, Stoker, N G, Nicole J. Moreland, Gurcha, Sudagar, Sharon L. Kendall, Lott, J Shaun, Kendall, S L, Stoker, Neil G, Lott, J S, Ten Bokum, Annemieke, Withers, M, Lott, JS, Annemieke Ten Bokum, Besra, Gurdyal S   +39 more
core   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source