Results 21 to 30 of about 1,738,596 (334)

m1-toxin

open access: yesLife Sciences, 1993
The venom of the Eastern green mamba from Africa, Dendroaspis angusticeps, contains a number of toxins which block the binding of 3H-antagonists to genetically-defined m1 and m4 muscarinic acetylcholine receptors. Most of the anti-muscarinic activity of the venom is due to the presence of a newly-isolated toxin, "m1-toxin", which has 64 amino acids and
L T, Potter   +6 more
openaire   +2 more sources

Cerebellum to motor cortex paired associative stimulation induces bidirectional STDP-like plasticity in human motor cortex [PDF]

open access: yes, 2012
The cerebellum is crucially important for motor control and adaptation. Recent non-invasive brain stimulation studies have indicated the possibility to alter the excitability of the cerebellum and its projections to the contralateral motor cortex, with ...
Lu, Ming-Kuei   +2 more
core   +1 more source

Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice

open access: yesFrontiers in Oncology, 2020
Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment have gained much interests as basic science regarding their roles in tumor progression unfolds. Better understanding of their polarization into pro-tumoral phenotype to
S. Jayasingam   +5 more
semanticscholar   +1 more source

Considerations in the Use of Work-From-Home (WFH) for Post-Pandemic Planning and Management

open access: yesManagement, 2021
after widespread use of work-from-home (a.k.a. ‘remote work’) during the COVID-19 pandemic, many organizations intend to continue or expand its use into the future.
Manko Barbara A.
doaj   +1 more source

The M1 and M2 paradigm of macrophage activation: time for reassessment

open access: yesF1000Prime Reports, 2014
Macrophages are endowed with a variety of receptors for lineage-determining growth factors, T helper (Th) cell cytokines, and B cell, host, and microbial products.
F. Martínez, S. Gordon
semanticscholar   +1 more source

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

open access: yesCell Death and Disease, 2021
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been ...
Z. Lv   +11 more
semanticscholar   +1 more source

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

open access: yesFrontiers in Immunology, 2019
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue macrophages are seeded in the early embryo before definitive hematopoiesis is established. Others are derived from blood monocytes.
Marco Orecchioni   +3 more
semanticscholar   +1 more source

Influenza A matrix protein M1 induces lipid membrane deformation via protein multimerization [PDF]

open access: yes, 2019
The matrix protein M1 of the Influenza A virus (IAV) is supposed to mediate viral assembly and budding at the plasma membrane (PM) of infected cells. In order for a new viral particle to form, the PM lipid bilayer has to bend into a vesicle toward the ...
Chiantia, Salvatore   +2 more
core   +1 more source

M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop

open access: yesJournal of experimental & clinical cancer research : CR, 2022
Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma (OSCC ...
Y. You   +7 more
semanticscholar   +1 more source

Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in apoE-deficient mice by activating platelets and leukocytes

open access: yesArchives of Medical Science, 2018
Introduction Exposure to the fine particulate matter PM2.5 is strongly associated with atherosclerotic diseases, creating considerable public concern. Nevertheless, the mechanisms have not been fully elucidated.
Xuecan Zhu   +6 more
doaj   +1 more source

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