Results 121 to 130 of about 1,872,691 (138)

TRMT6-mediated tRNA m1A modification acts as a translational checkpoint of histone synthesis and facilitates colorectal cancer progression

Nature Cancer
Transfer RNA modifications have emerged as critical regulators of translational reprogramming, yet their roles in colorectal cancer (CRC) remain largely elusive. Here, we find that tRNA N1-methyladenosine (m1A) methyltransferase TRMT6 is upregulated in human CRC tissues and high TRMT6 expression correlates with poor survival in patients with CRC. Using
E. Tao, Ye Wang, Juan Tan, Yan Chen, Tianyue Sun, Yu Hao, Hao-Lian Wang, Qianqian Liu, Yun-Qian Wang, Linna Fu, Zhi-Qing Zhan, Haoyan Chen, Jie Hong, Q. Gao, Jing-Yuan Fang, Yingxuan Chen   +15 more
semanticscholar   +3 more sources

m1A Modification: An Emerging Epitranscriptomic Regulator of Stem Cell Fate

Stem Cell Reviews and Reports
Ni Gan, Kang Yan, Jianbo Yang, Kangyuan Zou, Meilin Tan, Linru Zeng, Jun He, Xiangwen Peng, Sifeng Wang   +8 more
semanticscholar   +2 more sources

Involvement of RNA methylation modification patterns mediated by m7G, m6A, m5C and m1A regulators in immune microenvironment regulation of Sjögren's syndrome.

Cellular Signalling, 2023
Keratoconjunctivitis is the most common complication of Sjögren's syndrome (SS). It has always been a hot research topic due to its complex pathogenesis.
Yuxiu Liu, Jianing Zhu, Lin Ding
semanticscholar   +1 more source

tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells

Cell Discovery
Group 3 innate lymphoid cells (ILC3s) play crucial roles in maintaining intestinal homeostasis and defending against bacterial infections. However, the epigenetic mechanisms that regulate ILC3 responses are not well understood.
Jingyu Li, Zirun Tang, Yunzhu Chen, Xuemin Cai, Longyan Wu, Gaoyang Wang, Chen Kan, Bin Li, Bing Su, Huabing Li, Coco Chu, Huabing Li   +11 more
semanticscholar   +1 more source

m1A modification of tRNA in anaplastic thyroid cancer

This project aims to explore the impact of TRMT6/TRMT61A-mediated m1A modification of tRNA on the progression of anaplastic thyroid cancer and its molecular mechanism. The cells used in this study are human anaplastic thyroid cancer cells KHM-5M.
openaire   +1 more source

tsRNA-10547 generated by m1A modification-mediated tRNA shearing promotes colorectal cancer metastasis via suppressing CHRNA9.

Archives of Biochemistry and Biophysics
Transfer RNA-derived fragments (tsRNAs) are critical regulators in tumorigenesis, yet their specific roles in colorectal cancer (CRC) metastasis remain poorly characterized.
Xujun Song, Qinjie Liu, Qingsong Tao
semanticscholar   +1 more source

tRNA-m1A modification: a translational checkpoint for T cell expansion

Cell Research, 2022
Weike Pei, Vijay K. Kuchroo
openaire   +2 more sources

FourierAN-m1A: A Novel Fourier-Domain Adaptive Feature Extraction Framework for m1A RNA Modification Prediction.

ACS Synthetic Biology
RNA modifications play a pivotal role in regulating gene expression. Among them, N1-methyladenosine (m1A), as a crucial post-transcriptional modification, requires accurate site identification to elucidate its regulatory mechanisms.
Yifei Li, Junlei Yu, Wenjia Gao, Shaoye Zhang, Leyi Wei   +4 more
semanticscholar   +1 more source

The highly abundant mRNA m1A modification: a new layer of gene regulation in dinoflagellates

bioRxiv, 2023
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Jie Yuan, Jiawei Xu, Hao Chen   +9 more
semanticscholar   +1 more source

Comprehensive Analyses of M1A Regulator-Mediated Modification Patterns in Lower-Grade Glioma

2023
Kunjian Lei, Yilei Sheng, Min Luo, Junzhe Liu, chuandong gong, Xingen Zhu, Kai Huang, Jingying Li   +7 more
openaire   +1 more source