Results 101 to 110 of about 13,431 (216)

The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases

International Journal of Molecular Sciences
The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs).
xinxing liu, Yi Yu, Haiying Zhang, min zhang, yan liu   +4 more
openaire   +2 more sources

Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis

BMC Gastroenterology, 2010
Background Autoantibodies to the human muscarinic acetylcholine receptor of the M3 type (hmAchR M3) have been suggested to play an etiopathogenic role in Sjögren's syndrome.
Berg Peter A, Gregor Michael, Lauber Kirsten, Blume Karin, Berg Christoph P, Wesselborg Sebastian, Stein Gerburg M   +6 more
doaj   +1 more source

A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]

, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Marsango, Sara, Millan, Mark J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +6 more
core   +2 more sources

Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms

Frontiers in Cellular Neuroscience, 2019
In hippocampal CA1, muscarinic acetylcholine (ACh) receptor (mAChR) activation via exogenous application of cholinergic agonists has been shown to presynaptically inhibit Schaffer collateral (SC) glutamatergic inputs in stratum radiatum (SR), and ...
Priyodarshan Goswamee, A. Rory McQuiston
doaj   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, Volume 15, Issue 12, Page 1955-1962, December 2025.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors [PDF]

European Journal of Biochemistry, 1994
In human embryonic kidney cells stably expressing the human m3 muscarinic acetylcholine receptor (mAChR) subtype, agonist (carbachol) activation stimulated phospholipase C, increased cytoplasmic calcium concentration, induced tyrosine phosphorylation of various cellular proteins and activated phospholipase D. Bypassing membrane receptors, phospholipase
M, Schmidt, S M, Hüwe, B, Fasselt, D, Homann, U, Rümenapp, J, Sandmann, K H, Jakobs   +6 more
openaire   +2 more sources

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

, 2006
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
58998, 58999, IINO, Satoshi, NOJYO, Yoshiaki   +3 more
core   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, Volume 1, Issue 2, Page 154-170, December 2025.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

Neuronal Reshaping of the Tumor Microenvironment in Tumorigenesis and Metastasis: Bench to Clinic

Medicine Advances, Volume 3, Issue 4, Page 364-371, December 2025.
This graphical abstract illustrates the multidimensional crosstalk between neurons and tumor microenvironment as well as targeted intervention strategies identified in the study. It highlights three core interaction axes: nerve‐tumor crosstalk mediated by neurotransmitters and neurotrophic factors, neuro‐vascular communication driving angiogenesis via ...
Yimao Wu, Ruowei Sun, Shuai Ren, Gokhan Zengin, Mengyao Li   +4 more
wiley   +1 more source

Extrinsic intestinal denervation modulates tumor development in the small intestine of ApcMin/+ mice [PDF]

, 2015
Background Innervation interacts with enteric immune responses. Chronic intestinal inflammation is associated with increased risk of colorectal cancer. We aimed to study potential extrinsic neuronal modulation of intestinal tumor development in a mouse ...
Benhaqi, Petra, Dietrich, Alexandra, Kasparek, Michael S., Kreis, Martin E., Liu, Verena, Schemann, Michael, Schneider, Marlon R., Seeliger, Hendrik   +7 more
core   +2 more sources