Results 121 to 130 of about 63,662 (384)

Link Between m6A Modification and Cancers [PDF]

Frontiers in Bioengineering and Biotechnology, 2018
N6-methyladenosine (m6A) epitranscriptional modification has recently gained much attention. Through the development of m6A sequencing, the molecular mechanism and importance of m6A have been revealed. m6A is the most abundant internal modification in higher eukaryotic mRNAs, which plays crucial roles in mRNA metabolism and multiple biological ...
Zhen-Xian Liu, Li-Man Li, Hui-Lung Sun, Song-Mei Liu   +3 more
openaire   +3 more sources

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling

Frontiers in Bioscience-Landmark
Background: The importance of N6-methyladenosine (m6A) modification in tumorigenesis and progression have been highlighted. This study aimed to investigate the modification of insulin receptor substrate 1 (IRS1) by m6A and its role in oral squamous cell ...
Yanbo Xiao, Xuan Zhu, Qun Li, Zongkang Wang, Qiaojuan Zuo, Xun Liu, Jin Tan   +6 more
doaj   +1 more source

m6A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia

Epigenetics, 2023
Patients with acute myeloid leukaemia (AML) have poor prognoses and low overall survival (OS) rates owing to its heterogeneity and the complexity of its tumour microenvironment (TME).
Xinai Liao, Ling Chen, Jingru Liu, Haoran Hu, Diyu Hou, Ruolan You, Xiaoting Wang, Huifang Huang   +7 more
doaj   +1 more source

Star and protoplanetary disk properties in Orion's suburbs

, 2009
(Note: this is a shortened version of the original "structured" A&A format abstract.) We performed a large optical spectroscopic and photometric survey of the Lynds~1630N and 1641 clouds.
A. Carmona, A. Sicilia-Aguilar, Acke, Acke, Acke, Adams, Akeson, Akeson, Alcalá, Alexander, Allen, Alonso-Albi, Alves, Anderson, Andrews, Anthony-Twarog, Artymowicz, Bally, Baraffe, Barrado y Navascués, Barrado y Navascués, Bertout, Bouwman, Briceño, Briceño, Béjar, Calvet, Calvet, Calvet, Cardelli, Carpenter, Cieza, Cieza, Cieza, Clarke, Comerón, D'Alessio, D'Antona, Dahm, Dahm, Dahm, Dahm, Diolaiti, Dotter, Dullemond, Eisner, Eisner, Evans, Evans, Evans, Fazio, Fedele, Fedele, Finkbeiner, Flaherty, Furlan, Garcia Lopez, Gatti, Genzel, Gullbring, Gustafsson, Gutermuth, Gutermuth, Gâlfalk, Haisch, Hamann, Hartigan, Hartigan, Hartigan, Hartmann, Hartmann, Hartmann, Hartmann, Hartmann, Hartmann, Henning, Herbig, Herbig, Herczeg, Hernández, Hernández, Hernández, Hernández, Hillenbrand, Hillenbrand, Hillenbrand, Hirota, Huélamo, Isella, Kenyon, Kenyon, Kramer, Kraus, Kurucz, Kurucz, Kwan, Lada, Lada, Leinert, Lombardi, Luhman, Luhman, Luhman, M. Fang, Maddalena, Mamajek, Meeus, Megeath, Miesch, Mohanty, Monnier, Monnier, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Muzerolle, Najita, Natta, Natta, Osterloh, Quillen, R. van Boekel, Reipurth, Rice, Rieke, Román-Zúñiga, Rucinski, Sacco, Setiawan, Shu, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Sicilia-Aguilar, Siess, Siess, Skrutskie, Spezzi, Strom, Strom, Th. Henning, Valdes, van der Plas, Vinkovic, Vinkovic, W. Wang, White, Wilson, Winston, Young   +152 more
core   +2 more sources

Pitting damage levels estimation for planetary gear sets based on model simulation and grey relational analysis [PDF]

, 2011
The planetary gearbox is a critical mechanism in helicopter transmission systems. Tooth failures in planetary gear sets will cause great risk to helicopter operations.
Cheng, Zhe, Gu, Fengshou, Hu, Niaoqing, Qin, Guojun   +3 more
core   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

Epigenetics, 2022
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related protein (FTO) promote the growth, migration and invasion of PC.
Wei Wang, Ying He, Lu-Lu Zhai, Long-Jiang Chen, Li-Chao Yao, Lun Wu, Zhi-Gang Tang, Jin-Zhuo Ning   +7 more
doaj   +1 more source

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]

, 2019
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng, Huang, Mengjiang, Li, Dongxu, Lu, Jiuwei, Ren, Wendan, Song, Jikui, Wang, Gang Greg   +6 more
core  

Probing the structure of the cold dark matter halo with ancient mica

, 1997
Mica can store (for >1 Gy) etchable tracks caused by atoms recoiling from WIMPs. Ancient mica is a directional detector despite the complex motions it makes with respect to the WIMP "wind".
Andrew J. Westphal, C. Lacey, C. Lacey, D. P. Snowden-Ifft, D. P. Snowden-Ifft, D. P. Snowden-Ifft, Daniel P. Snowden-Ifft, E. R. Capriotti, Edward A. Baltz, G. Jungman, J. Binney, J. F. Navarro, J. F. Navarro, J. F. Navarro, K. V. Johnston, L. Hernquist, R. Bernabei, V. Trimble, W. H. Press   +18 more
core   +1 more source