Results 131 to 140 of about 58,783 (322)

The Activation of M1 Macrophages is Associated with the JNK-m6A-p38 Axis in Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2023
Tingting Hu,1,* Nannan Pang,2,* Zheng Li,1 Dan Xu,1 Jing Jing,1 Fengsen Li,1 Jianbing Ding,3 Jing Wang,1 Min Jiang1 1Xinjiang Laboratory of Respiratory Disease Research, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical ...
Hu T, Pang N, Li Z, Xu D, Jing J, Li F, Ding J, Wang J, Jiang M   +8 more
doaj  

Non-Gaussianity from Lifshitz Scalar

, 2010
A Lifshitz scalar with the dynamical critical exponent z = 3 obtains scale-invariant, super-horizon field fluctuations without the need of an inflationary era.
, B. Chen, C. Charmousis, C. Cheung, C. Cheung, C.T. Byrnes, C.T. Byrnes, D. Babich, D. Langlois, D. Langlois, D. Seery, D. Seery, D. Seery, D. Seery, E. Komatsu ., F. Arroja, G. Calcagni, H.R.S. Cogollo, J. Khoury, J.M. Maldacena, K. Izumi, Keisuke Izumi, L. Kofman, L. Senatore, M. Kawasaki, N. Arkani-Hamed, N. Bartolo, P. Creminelli, Q.-G. Huang, Q.-G. Huang, Q.-G. Huang, R. Holman, S. Mizuno, S. Mukohyama, S. Mukohyama, S. Mukohyama, S. Renaux-Petel, Shinji Mukohyama, T. Harada, T. Kobayashi, T. Suyama, Takeshi Kobayashi, X. Chen, X. Chen, X. Chen, X. Chen, X. Gao, X. Gao, X. Gao, X. Gao   +49 more
core   +1 more source

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Associated Production of Bottomonia and Higgs Bosons at Hadron Colliders [PDF]

, 2004
We study the associated production of bottomonia and Higgs bosons at hadron colliders within the factorization formalism of nonrelativistic quantum chromodynamics providing all contributing partonic cross sections in analytic form.
A. Martin, A. Petrelli, A.K. Leibovich, A.V. Lipatov, B. Abbott, B. Humpert, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, Bernd A. Kniehl, C. Adloff, C. Adloff, C. Quigg, Caesar P. Palisoc, D. Acosta, D. Acosta, E. Braaten, E. Braaten, E. Braaten, E. Braaten, E. Braaten, E. Eichten, E. Eichten, E. Eichten, E.J. Eichten, E.L. Berger, F. Abe, F. Abe, F. Abe, F. Abe, F. Abe, F. Halzen, F. Maltoni, F. Yuan, F. Yuan, G.A. Schuler, G.T. Bodwin, G.T. Bodwin, H. Fritzsch, H.L. Lai, J. Abdallah, J.F. Amundson, K. Hagiwara, K. Sridhar, Lennart Zwirner, M. Beneke, M. Beneke, M. Glück, M. Klasen, M. Krämer, M. Spira, N. Marchal, P. Cho, P. Cho, P. Hoyer, Ph. Hägler, Ph. Hägler, R. Baier, R. Baier, R. Barbieri, R. Gastmans, R. Gastmans, S. Abachi, S. Fleming, S.P. Baranov, V. Barger, V.A. Saleev, V.A. Saleev, W. Buchmüller, W.E. Caswell   +72 more
core   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source

m6A modification in cancer regulation: molecular circuits and regulatory networks

Visualized Cancer Medicine
The N6-methyladenosine (m6A) modification is a significant research direction in the field of epitranscriptomics, and its multifaceted functions in tumor regulation have garnered increasing attention.
Li Yiming, Zhu Kunrui, Feng Yanqi, Yao Shuxi, Han Yuelin, Xiao Xiangtian, Han Zhuoyan, Xia Shu   +7 more
doaj   +1 more source

Probing the structure of the cold dark matter halo with ancient mica

, 1997
Mica can store (for >1 Gy) etchable tracks caused by atoms recoiling from WIMPs. Ancient mica is a directional detector despite the complex motions it makes with respect to the WIMP "wind".
Andrew J. Westphal, C. Lacey, C. Lacey, D. P. Snowden-Ifft, D. P. Snowden-Ifft, D. P. Snowden-Ifft, Daniel P. Snowden-Ifft, E. R. Capriotti, Edward A. Baltz, G. Jungman, J. Binney, J. F. Navarro, J. F. Navarro, J. F. Navarro, K. V. Johnston, L. Hernquist, R. Bernabei, V. Trimble, W. H. Press   +18 more
core   +1 more source

tRNA biology in the omics era: Stress signalling dynamics and cancer progression. [PDF]

, 2017
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell ...
Adelman, Anderson, Anderson, Arimbasseri, Arimbasseri, Barski, Bartholomew, Basturea, Behm-Ansmant, Blanco, Bogenhagen, Boguta, Bonhoure, Canella, Canella, Carlile, Carrire, Chan, Chan, Choi, Clarke, Conti, Core, Cozen, Crick, Danko, David, de Nadal, Deng, Dieci, Dittmar, Dittmar, Duechler, Ebhardt, Flusberg, Gingold, Goodarzi, Goodarzi, Granneman, Grewal, Guenther, Guy, Harismendy, Hiley, Hoagland, Holley, Honda, Hou, Huang, Hussain, Iida, Ishimura, Ivanov, Johnson, Jordan-Pla, Kadaba, Kassavetis, Kedinger, Khoddami, Kim, Kumar, Kumar, Kumar, Kutter, Lampson, Laplante, Li, Li, Lin, Linder, Liu, Liu, Lowe, Lund, Mahlab, Marchand, Mayer, Michels, Moqtaderi, Moqtaderi, Nagarajavel, Nedialkova, Noma, Oler, Oler, Orioli, Orioli, Pang, Pavesi, Pavon-Eternod, Pavon-Eternod, Percudani, Pershing, Phizicky, Pombo, Pugh, Qian, Raha, Renaud, Rhee, Rideout, Roberts, Roeder, Ross, Rudolph, Ryvkin, Saikia, Saikia, Sakurai, Sakurai, Schaefer, Schmitt, Schwartz, Shor, Shukla, Simms, Sutherland, Thurman, Torres, Torres, Turowski, Vannini, Varshney, Vilfan, Weinmann, White, Zheng, Zhou   +127 more
core   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source