Results 181 to 190 of about 58,783 (322)
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, EarlyView.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
Zoo Biology, EarlyView.First successful vasectomy in a southern African male giraffe, Giraffa camelopardis giraffa ABSTRACT This study reports the first successful vasectomy on a southern African male giraffe (Giraffa camelopardalis giraffa). The goal of the procedure was to create a teaser male for reproductive studies.
Francois Deacon +7 more
wiley +1 more source
m6A-mediated translation regulation [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 openaire +2 more sources
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Cancer Science, EarlyView.FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang +7 more
wiley +1 more source
Genetic networks controlling retinal injury. [PDF]
, 2005 PURPOSE: The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury. METHODS: A group of acute phase genes expressed in diverse nervous system tissues was defined by combining microarray results from ...
Chan, Chun K +10 more
core +1 more source
Cancer Science, EarlyView.Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao +6 more
wiley +1 more source
Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases
Cell Proliferation, EarlyView.Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long +6 more
wiley +1 more source
Cell Proliferation, EarlyView.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
European Journal of Medical ResearchBackground Effective biomarkers for esophageal carcinoma (ESCA) are currently lacking. Here, we examined the role of minichromosome maintenance complex component 8 (MCM8) as a diagnostic and prognostic marker in ESCA and its association with m6a ...
Xu-Sheng Liu +7 more
doaj +1 more source