Results 11 to 20 of about 58,783 (322)
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Molecular Cancer, 2022 Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Lijuan Deng +10 more
semanticscholar +1 more source
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
core +3 more sources
eLife, 2021 Gene regulation via N6-methyladenosine (m6A) in mRNA involves RNA-binding proteins that recognize m6A via a YT521-B homology (YTH) domain. The plant YTH domain proteins ECT2 and ECT3 act genetically redundantly in stimulating cell proliferation during ...
Laura Arribas-Hernández +7 more
doaj +1 more source
m6A RNA methylation: from mechanisms to therapeutic potential
EMBO Journal, 2021 RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N6‐methyladenosine (m6A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification ...
P. He, Chuan He
semanticscholar +1 more source
Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval
NeuroImage, 2020 Autobiographical memory (AM) unfolds over time, but little is known about the dynamics of its retrieval. Space-based models of memory implicate the hippocampus, retrosplenial cortex, and precuneus in early memory computations.
Melissa Hebscher +2 more
doaj +1 more source
Genome Biology, 2021 Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu +6 more
semanticscholar +1 more source
RNA Modification in Carcinogenesis and Development of Gastric Cancer
Zhongliu Fangzhi Yanjiu, 2023 The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics.
XU Jiawen, WANG Qiang, WANG Shouyu
doaj +1 more source
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
Nature Communications, 2021 N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown.
Huilong Yin +13 more
semanticscholar +1 more source
RNA modification-mediated translational control in immune cells
RNA Biology, 2023 RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment.
Yujuan Zhang, Weiguo Hu, Hua-Bing Li
doaj +1 more source
A comprehensive review of m6A/m6Am RNA methyltransferase structures
Nucleic Acids Research, 2021 Gene expression is regulated at many levels including co- or post-transcriptionally, where chemical modifications are added to RNA on riboses and bases.
S. Oerum +3 more
semanticscholar +1 more source