Results 11 to 20 of about 63,662 (384)
RNA m6A methylation across the transcriptome.
Molecular Cell, 2023 Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem Sendinc, Yang Shi
semanticscholar +3 more sources
Reading m6A in the Transcriptome: m6A-Binding Proteins [PDF]
Trends in Cell Biology, 2018 N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA and long noncoding RNA. m6A mediates its effects primarily by recruiting proteins, including the multiprotein eukaryotic initiation factor 3 complex and a set of proteins that contain the YTH domain.
Deepak P, Patil +2 more
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Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma
Frontiers in Cell and Developmental Biology, 2022 N6-methyladenosine (m6A) modification is one of the most prevalent RNA modification forms and is an important posttranscriptional mechanism for regulating genes. In previous research, we found that m6A regulator–mediated RNA methylation modification was involved in asthma; however, the specific modified genes are not clear.
Deyang Sun +9 more
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Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
core +3 more sources
m6A RNA methylation: from mechanisms to therapeutic potential
EMBO Journal, 2021 RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N6‐methyladenosine (m6A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification ...
P. He, Chuan He
semanticscholar +1 more source
A comprehensive review of m6A/m6Am RNA methyltransferase structures
Nucleic Acids Research, 2021 Gene expression is regulated at many levels including co- or post-transcriptionally, where chemical modifications are added to RNA on riboses and bases.
S. Oerum +3 more
semanticscholar +1 more source
eLife, 2021 Gene regulation via N6-methyladenosine (m6A) in mRNA involves RNA-binding proteins that recognize m6A via a YT521-B homology (YTH) domain. The plant YTH domain proteins ECT2 and ECT3 act genetically redundantly in stimulating cell proliferation during ...
Laura Arribas-Hernández +7 more
doaj +1 more source
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
Molecular Cancer, 2021 RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA ...
P. Nombela +2 more
semanticscholar +1 more source
Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval
NeuroImage, 2020 Autobiographical memory (AM) unfolds over time, but little is known about the dynamics of its retrieval. Space-based models of memory implicate the hippocampus, retrosplenial cortex, and precuneus in early memory computations.
Melissa Hebscher +2 more
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RNA Modification in Carcinogenesis and Development of Gastric Cancer
Zhongliu Fangzhi Yanjiu, 2023 The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics.
XU Jiawen, WANG Qiang, WANG Shouyu
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