Results 11 to 20 of about 36,922 (295)

Reading m6A in the Transcriptome: m6A-Binding Proteins [PDF]

Trends in Cell Biology, 2018
N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA and long noncoding RNA. m6A mediates its effects primarily by recruiting proteins, including the multiprotein eukaryotic initiation factor 3 complex and a set of proteins that contain the YTH domain.
Deepak P Patil, Brian F Pickering, Samie R Jaffrey   +2 more
exaly   +3 more sources

Adaptive Syllable Training Improves Phoneme Identification in Older Listeners with and without Hearing Loss

Audiology Research, 2022
Acoustic-phonetic speech training mitigates confusion between consonants and improves phoneme identification in noise. A novel training paradigm addressed two principles of perceptual learning.
Annette Schumann, Bernhard Ross
doaj   +1 more source

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
doaj   +1 more source

Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma

Frontiers in Cell and Developmental Biology, 2022
N6-methyladenosine (m6A) modification is one of the most prevalent RNA modification forms and is an important posttranscriptional mechanism for regulating genes. In previous research, we found that m6A regulator–mediated RNA methylation modification was involved in asthma; however, the specific modified genes are not clear.
Deyang Sun, Xiaolu Cai, Fenglin Shen, Liming Fan, Huan Yang, Suqun Zheng, Linshui Zhou, Ke Chen, Zhen Wang, Zhen Wang   +9 more
openaire   +3 more sources

MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6

Chinese Journal of Physiology, 2023
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease.
Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge   +4 more
doaj   +1 more source

Epitranscriptomics in the Heart: a Focus on m6A [PDF]

Current Heart Failure Reports, 2020
Post-transcriptional modifications are key regulators of gene expression that allow the cell to respond to environmental stimuli. The most abundant internal mRNA modification is N6-methyladenosine (m6A), which has been shown to be involved in the regulation of RNA splicing, localization, translation, and decay.
Jacob Z, Longenecker, Christopher J, Gilbert, Volha A, Golubeva, Colton R, Martens, Federica, Accornero   +4 more
openaire   +2 more sources

RNA N6-Methyladenosine Regulators Contribute to Tumor Immune Microenvironment and Have Clinical Prognostic Impact in Breast Cancer

Frontiers in Genetics, 2022
Purpose: This study aims to reveal the relationship between RNA N6-methyladenosine (m6A) regulators and tumor immune microenvironment (TME) in breast cancer, and to establish a risk model for predicting the occurrence and development of tumors.Patients ...
Lan-Xin Mu, You-Cheng Shao, Lei Wei, Fang-Fang Chen, Jing-Wei Zhang   +4 more
doaj   +1 more source

The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

eLife, 2021
Gene regulation via N6-methyladenosine (m6A) in mRNA involves RNA-binding proteins that recognize m6A via a YT521-B homology (YTH) domain. The plant YTH domain proteins ECT2 and ECT3 act genetically redundantly in stimulating cell proliferation during ...
Laura Arribas-Hernández, Sarah Rennie, Michael Schon, Carlotta Porcelli, Balaji Enugutti, Robin Andersson, Michael D Nodine, Peter Brodersen   +7 more
doaj   +1 more source

CTLife/m6A-SAC-seq: m6A-SAC-seq v0.2

, 2022
Perl, Bash shell, and R scripts for m6A-SAC-seq data ...
Source Codes for Computational and Theoretical Life Science
core   +1 more source

Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval

NeuroImage, 2020
Autobiographical memory (AM) unfolds over time, but little is known about the dynamics of its retrieval. Space-based models of memory implicate the hippocampus, retrosplenial cortex, and precuneus in early memory computations.
Melissa Hebscher, Christine Ibrahim, Asaf Gilboa   +2 more
doaj   +1 more source