Results 211 to 220 of about 63,662 (384)

m6A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway [PDF]

open access: gold
Jian-Fei Xi   +13 more
openalex   +1 more source

First Vasectomy Procedure Successfully Performed on a Southern African Male Giraffe (Giraffa camelopardalis giraffa)

open access: yesZoo Biology, EarlyView.
First successful vasectomy in a southern African male giraffe, Giraffa camelopardis giraffa ABSTRACT This study reports the first successful vasectomy on a southern African male giraffe (Giraffa camelopardalis giraffa). The goal of the procedure was to create a teaser male for reproductive studies.
Francois Deacon   +7 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang   +18 more
wiley   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

open access: yesCancer Science, EarlyView.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki   +3 more
wiley   +1 more source

The potential of MCM8 as a biomarker in esophageal carcinoma: a comprehensive analysis integrating m6a methylation and angiogenesis

open access: yesEuropean Journal of Medical Research
Background Effective biomarkers for esophageal carcinoma (ESCA) are currently lacking. Here, we examined the role of minichromosome maintenance complex component 8 (MCM8) as a diagnostic and prognostic marker in ESCA and its association with m6a ...
Xu-Sheng Liu   +7 more
doaj   +1 more source

m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome

open access: yesNature Biotechnology, 2022
Lulu Hu   +17 more
semanticscholar   +1 more source

M6A modification in cardiovascular disease: With a focus on programmed cell death

open access: diamond, 2023
Wen Li   +6 more
openalex   +1 more source

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation

open access: yesCancer Science, EarlyView.
ABSTRACT Succinylation has been shown to promote lung cancer development, but its mechanism remains incompletely understood. KAT2A, a succinyltransferase, acts as an oncogene in multiple cancers, but its role in mediating lung cancer progression is unclear.
Junping Li   +7 more
wiley   +1 more source

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