Results 221 to 230 of about 58,783 (322)

P450 engineering via structure-guided rational design achieves high C21-selectivity and bioconversion in steroid biosynthesis. [PDF]

Synth Syst Biotechnol
Yang J, Li R, Gao Q, Ma L, Wang Q, Ma G, Fan Y, Li S, Xu LH.   +8 more
europepmc   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

RBM15B promotes hepatocellular carcinoma progression via IGF2BP1-mediated ITSN2 mRNA stabilization. [PDF]

J Cancer Res Clin Oncol
Xu Y, Xiong M, Chen W, Yao C, Chen Y, Man D, Xie H, Ye X, Jia C.   +8 more
europepmc   +1 more source

m6A deposition: a boost from TGFβ [PDF]

Cell Research, 2018
Lior Lasman, Jacob H. Hanna
openaire   +2 more sources

CRISPR Assays for Protein Detection

Chemistry–Methods, Volume 6, Issue 3, March 2026.
This review summarizes recent advances in CRISPR–Cas–based strategies for protein detection. Particular focus is placed on recognition element–based approaches, in which antibodies, aptamers, or DNAzymes convert protein binding into CRISPR‐readable nucleic acid signals, and activity‐based strategies that exploit intrinsic protein functions to trigger ...
Luca Capelli, Elena Spezzani, Dharshini Raghavan, Chiara Micucci, Alessandra Zanut, Alessandro Bertucci   +5 more
wiley   +1 more source

Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition of m⁶A. [PDF]

RNA Biol
Park R, Demny M, Miller LG, Pedraza C, Xenophontos X, Hunt RK, Orr AA, Perez LM, Montalbano M, Contreras LM, Tamamis P.   +10 more
europepmc   +1 more source

m6A modulates RNA structure [PDF]

Nature Reviews Molecular Cell Biology, 2015
openaire   +1 more source

Cell‐Type‐Specific WTAP and ALKBH5‐Mediated m6A Methylation Orchestrates Mental Disorders via Gut‐Brain Axis Metabolite Signaling: Multi‐Omics Evidence and Pyroptosis‐Associated Loop Mechanism

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
MR analysis revealed distinct causal associations of m6A modifiers (WTAP/ALKBH5) with mental disorders. Gut microbiota (GCA‐900066755, Bacillus) and CSF metabolites (theophylline, isoleucine) mediated 5.06%–45.28% of effects via pathways such as WTAP → GCA‐900066755 → theophylline → ADHD. Single‐cell eQTL linked WTAP‐mediated ADHD risk to XCL1‐NK cells,
Jingjing Zhang, Xue Liu, Xiaoming Liu, Liqun Zhao, Junjie Bi   +4 more
wiley   +1 more source

Nanopore direct RNA sequencing for RNA modification analysis: workflow assessment and computational tool benchmarking. [PDF]

Adv Biotechnol (Singap)
Wu Z, Li J, Xia R, Dai J, Su J, Meng J, Zhang Y.   +6 more
europepmc   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source