Results 251 to 260 of about 58,783 (322)

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

The dynamic landscape and conserved regulation of the m6Am and m6A methylomes during the human and mouse oocyte-to-embryo transition. [PDF]

Nucleic Acids Res
Su R, Du Z, Li S, Liu H, Gao D, Zhan S, Li C, Meng TG, Chen LN, Fan LH, Dong Y, Jiang S, Guo Z, Li L, Luo SM, Sun QY, Ou XH.   +16 more
europepmc   +1 more source

Reducing data processing effort in camera trap density estimation: Extending the REST model by explicitly modelling animal detection processes

Methods in Ecology and Evolution, Volume 17, Issue 3, Page 850-862, March 2026.
Abstract Accurate and reliable estimation of wildlife population density is fundamental to effective conservation and management. While camera traps show potential for monitoring ground‐dwelling mammal densities, labour‐intensive data processing remains a significant constraint. Ideally, conservation efforts would benefit from the continuous monitoring
Yoshihiro Nakashima, Gota Yajima, Ryo Matsuoka   +2 more
wiley   +1 more source

Emerging roles of RNA m⁶A modification in multiple myeloma pathogenesis and treatment resistance (Review). [PDF]

Int J Oncol
Maimaitiyiming Y, Hu S, Bai D, Guan Y, Bu N, Hao W, Maimaiti M.   +6 more
europepmc   +1 more source

Select Small Non‐Coding RNAs Are Determinants of Survival in Older Adults

Aging Cell, Volume 25, Issue 3, March 2026.
Circulating small RNAs were profiled by RNA sequencing in a well‐characterized cohort and evaluated alongside 187 clinical variables to predict survival. Models incorporating circulating small RNAs, including parsimonious subsets, outperformed age and clinical factors alone (AUC), with causal analyses supported by experimental evidence from the ...
Virginia Byers Kraus, Sisi Ma, Syeda Iffat Naz, Xin Zhang, Christopher G. Vann, Melissa C. Orenduff, William E. Kraus, Steven Shen, Janet L. Huebner, Ching‐Heng Chou, Erich Kummerfeld, Harvey Jay Cohen, Constantin F. Aliferis   +12 more
wiley   +1 more source

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation

Cancer Science, Volume 117, Issue 3, Page 631-643, March 2026.
ABSTRACT Succinylation has been shown to promote lung cancer development, but its mechanism remains incompletely understood. KAT2A, a succinyltransferase, acts as an oncogene in multiple cancers, but its role in mediating lung cancer progression is unclear.
Junping Li, Feng Zhao, Zhongchao Wang, Shaojun Yang, Zhichao Lu, Xiaoyan Li, Jincheng Song, Zhaoxia Dai   +7 more
wiley   +1 more source

Insulin signaling pathway related m⁶A methylated biomarker for type 2 diabetes and the potential modulation mechanism. [PDF]

Nutr Metab (Lond)
Dong J, Zhang Y, Li YL, Wu LJ, Wang S, Chen N, Yan YX.   +6 more
europepmc   +1 more source

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Prostate cancer is an aggressive disease with limited quantifiable biomarkers. One gene of interest is ODC1, which encodes ornithine decarboxylase, the rate‐limiting enzyme converting ornithine to putrescine in polyamine metabolism. Although ODC1 is known to be involved in prostate cancer development, exactly how it drives the disease ...
Jian Ma, Ting Pan, Shengli Sun, Musitapa Mutalifu, Wei Yang, Yue Niu, Peng Chen   +6 more
wiley   +1 more source

Single-cell and machine learning approaches reveal METTL14-mediated autophagy via PI3K/AKT signaling in invasive PitNET. [PDF]

Cancer Cell Int
Yang S, Pu C, Deng C, Bai X, Tian C, Zhang W, Deng K, Duan L, Lu L, Zhu H, Yao Y, Wang R, Chang M, Feng M.   +13 more
europepmc   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 387-403, March 2026.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source