Results 261 to 270 of about 40,511 (310)

METTL14-Mediated N6-Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4-Dependent Ferroptosis. [PDF]

MedComm (2020)
Sang A, Zhang Q, Zhou X, Wang X, Wang J, Song X, Li L, Li L, Li X.   +8 more
europepmc   +1 more source

METTL14-Mediated lncRNA MSTRG.292666.16 m⁶A Modification Promotes the Progression of Non-Small-Cell Lung Cancer Through the MAPK Pathway. [PDF]

Int J Mol Sci
Deng Q, Sun H, Wang H, Cai C, Ji X, Fang Q, Xie B, Zhou S.   +7 more
europepmc   +1 more source

Reading m6A in the Transcriptome: m6A-Binding Proteins [PDF]

Trends in Cell Biology, 2018
N6-Methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA and long noncoding RNA. m6A mediates its effects primarily by recruiting proteins, including the multiprotein eukaryotic initiation factor 3 complex and a set of proteins that contain the YTH domain.
Deepak P Patil, Samie R. Jaffrey
exaly   +3 more sources

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Mapping single-nucleotide m6A by m6A-REF-seq

Methods, 2022
The past few years have witnessed rapid progress in the field of RNA modifications. As the most prevailing modification on eukaryotic mRNA, m6A is characterized to play a vital role in various cellular activities. However, limitations of the detection method impede functional studies of m6A. Here we introduce m6A-REF-seq, a powerful and straightforward
Hong-Xuan, Chen, Zhang, Zhang, Dong-Zhao, Ma, Li-Qian, Chen, Guan-Zheng, Luo   +4 more
openaire   +2 more sources

m6A-SAC-seq for quantitative whole transcriptome m6A profiling

Nature Protocols, 2022
N6-methyladenosine (m6A) is the most abundant mRNA modification in mammalian cells, regulating many physiological processes. Here we describe a method for base-resolution, quantitative m6A sequencing in the whole transcriptome. The enzyme and small-molecule cofactor used in this protocol are prepared by recombinant protein expression and organic ...
Ruiqi Ge, Chang Ye, Yong Peng, Qing Dai, Yutao Zhao, Shun Liu, Pingluan Wang, Lulu Hu, Chuan He   +8 more
openaire   +2 more sources

m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer

Journal of Molecular Endocrinology, 2023
Epitranscriptomic modification of RNA regulates human development, health, and disease. The true diversity of the transcriptome in breast cancer including chemical modification of transcribed RNA (epitranscriptomics) is not well understood due to limitations of technology and bioinformatic analysis.
Belinda J Petri, Carolyn M Klinge
openaire   +2 more sources

m6A-Maize: Weakly supervised prediction of m6A-carrying transcripts and m6A-affecting mutations in maize (Zea mays)

Methods, 2022
With the rapid development of high-throughput sequencing techniques nowadays, extensive attention has been paid to epitranscriptomics, which covers more than 150 distinct chemical modifications to date. Among that, N6-methyladenosine (m6A) modification has the most abundant existence, and it is also significantly related to varieties of biological ...
Zhanmin, Liang, Lei, Zhang, Haoting, Chen, Daiyun, Huang, Bowen, Song   +4 more
openaire   +2 more sources

The epitranscriptome beyond m6A

Nature Reviews Genetics, 2020
Following its transcription, RNA can be modified by >170 chemically distinct types of modifications - the epitranscriptome. In recent years, there have been substantial efforts to uncover and characterize the modifications present on mRNA, motivated by the potential of such modifications to regulate mRNA fate and by discoveries and advances in our ...
David Wiener, Schraga Schwartz
openaire   +2 more sources